Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PARP15 | Q460N3 | 1/20 | 0.42 |
| ▸ | PARP10 | Q53GL7 | 1/20 | 0.42 |
| ▸ | NR3C1 | P04150 | 2/20 | 0.42 |
| ▸ | PGR | P06401 | 2/20 | 0.42 |
| ▸ | NR3C2 | P08235 | 2/20 | 0.42 |
| ▸ | AR | P10275 | 2/20 | 0.42 |
| ▸ | CNR2 | P34972 | 2/20 | 0.42 |
| ▸ | NNMT | P40261 | 1/20 | 0.41 |
| ▸ | TACR3 | P29371 | 1/20 | 0.40 |
| ▸ | ROCK2 | O75116 | 1/20 | 0.40 |
| ▸ | ROCK1 | Q13464 | 1/20 | 0.40 |
| ▸ | PDE7A | Q13946 | 1/20 | 0.39 |
| ▸ | POLB | P06746 | 2/20 | 0.39 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.39 |
| ▸ | GSK3B | P49841 | 1/20 | 0.38 |
| ▸ | CDC7 | O00311 | 1/20 | 0.38 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.38 |
| ▸ | MEN1 | O00255 | 1/20 | 0.38 |
| ▸ | MAPT | P10636 | 1/20 | 0.38 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL25148626 | 1.00 | PARP15 (0.42) | PARP15PARP10NR3C1PGRNR3C2 | |
| SCHEMBL25148734 | 0.86 | PDCD1 (0.44) | CNR2TACR3POLBTDP1KDM4E | |
| SCHEMBL30364876 | 0.86 | PDCD1 (0.44) | CNR2TACR3POLBTDP1KDM4E | |
| SCHEMBL25149632 | 0.83 | NNMT (0.41) | NR3C1PGRNR3C2ARNNMT | |
| SCHEMBL25149446 | 0.83 | ROCK2 (0.39) | NR3C1PGRNR3C2ARNNMT | |
| SCHEMBL25148803 | 0.82 | NR3C1 (0.40) | PARP15PARP10NR3C1PGRNR3C2 | |
| SCHEMBL4153908 | 0.81 | NNMT (0.47) | PARP15PARP10CNR2NNMTPDE7A | |
| SCHEMBL30364997 | 0.73 | LMNA (0.44) | CNR2TACR3POLBMEN1MAPT | |
| SCHEMBL21906150 | 0.73 | PARP1 (0.38) | PARP15PARP10CDC7KDM4EMEN1 | |
| SCHEMBL28014566 | 0.72 | NNMT (0.51) | NNMTPOLBTDP1KDM4EMEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2023062575-A1 | CYCLIC VINYL SULFONE COMPOUNDS AS WRN INHIBITORS | IDEAYA BIOSCIENCES, INC. (US) | 2023-04-20 | — | — | WO | disclosed |