SCHEMBL25169963

SCHEMBL25169963

O=C(O)c1nn[nH]c1Oc1ccc(-c2ccccc2F)cc1F

nearest known ligand 0.43

Predicted protein targets (top 16)

geneUniProtsupporting neighboursconfidence
▸ HAO1 Q9UJM8 2/20 0.43
▸ ACMSD Q8TDX5 1/20 0.43
▸ DHODH Q02127 6/20 0.40
▸ FEN1 P39748 2/20 0.39
▸ PRKAB2 O43741 1/20 0.38
▸ PRKAG1 P54619 1/20 0.38
▸ PRKAA2 P54646 1/20 0.38
▸ PRKAA1 Q13131 1/20 0.38
▸ PRKAG3 Q9UGI9 1/20 0.38
▸ PRKAG2 Q9UGJ0 1/20 0.38
▸ PRKAB1 Q9Y478 1/20 0.38
▸ TRPA1 O75762 1/20 0.37
▸ MIF P14174 1/20 0.37
▸ FFAR1 O14842 1/20 0.37
▸ FFAR4 Q5NUL3 3/20 0.36
▸ CTSA P10619 1/20 0.36

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL23319898 0.87 DHODH (0.40) HAO1DHODHFEN1FFAR4
SCHEMBL21296864 0.84 PPARG (0.43) HAO1ACMSDDHODHFEN1PRKAB2
SCHEMBL29799096 0.84 ACMSD (0.40) HAO1ACMSDDHODHFFAR1
SCHEMBL21296886 0.84 ACMSD (0.40) HAO1ACMSDDHODHFFAR1
SCHEMBL21312456 0.84 CXCL8 (0.43) HAO1
SCHEMBL24154728 0.81 KIF11 (0.40) HAO1DHODH
SCHEMBL24154724 0.80 HAO1 (0.40) HAO1DHODHPRKAB2PRKAG1PRKAA2
SCHEMBL24154729 0.80 HAO1 (0.40) HAO1DHODH
SCHEMBL23319989 0.79 HAO1 (0.42) HAO1
SCHEMBL23001722 0.79 HAO1 (0.69) HAO1FFAR1FFAR4

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-20230143491-A1 TRIAZOLE GLYCOLATE OXIDASE INHIBITORS PHOENIX TISSUE REPAIR, INC. 2023-05-11 — — US disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20230143491-A1 TRIAZOLE GLYCOLATE OXIDASE INHIBITORS XDH, DUOX1, PNPO HAO1 6/4885ACMSD 1728/4885DHODH 82/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.

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