SCHEMBL25185035

SCHEMBL25185035

COc1ccc(/C=C/C(=O)c2ccc(O)cc2)cc1F

nearest known ligand 0.78

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
▸ TUBB1 Q9H4B7 2/20 0.72
▸ CTSL P07711 2/20 0.72
▸ MEN1 O00255 4/20 0.68
▸ KMT2A Q03164 4/20 0.68
▸ ABCG2 Q9UNQ0 3/20 0.68
▸ CA1 P00915 2/20 0.65
▸ CA2 P00918 2/20 0.65
▸ ALDH1A1 P00352 3/20 0.65
▸ LMNA P02545 2/20 0.65
▸ KDM4E B2RXH2 1/20 0.65
▸ CXCL12 P48061 1/20 0.64
▸ CAPN1 P07384 2/20 0.63
▸ MAPT P10636 3/20 0.62
▸ P4HB P07237 1/20 0.62
▸ CALM1 P0DP23 1/20 0.62
▸ RAB9A P51151 1/20 0.62
▸ F3 P13726 1/20 0.62
▸ XDH P47989 1/20 0.62
▸ TNFRSF1A P19438 1/20 0.61
▸ CTSB P07858 1/20 0.60

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL3260873 0.89 TNFRSF1A (0.78) TUBB1MEN1KMT2AABCG2ALDH1A1
SCHEMBL3260868 0.89 TNFRSF1A (0.78) TUBB1MEN1KMT2AABCG2ALDH1A1
SCHEMBL30383289 0.87 ABCG2 (0.88) CTSLMEN1KMT2AABCG2CA1
SCHEMBL3440660 0.87 ABCG2 (0.88) CTSLMEN1KMT2AABCG2CA1
SCHEMBL30415470 0.87 ABCG2 (0.88) CTSLMEN1KMT2AABCG2CA1
SCHEMBL25199646 0.87 ABCG2 (0.88) CTSLMEN1KMT2AABCG2CA1
SCHEMBL3440656 0.87 ABCG2 (0.88) CTSLMEN1KMT2AABCG2CA1
SCHEMBL30384263 0.87 ABCG2 (0.88) CTSLMEN1KMT2AABCG2CA1
SCHEMBL25197210 0.86 CTSL (0.76) TUBB1CTSLMEN1KMT2AABCG2
SCHEMBL25184983 0.86 CTSL (0.76) TUBB1CTSLMEN1KMT2AABCG2

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-20260014100-A1 Compositions and Methods for Treating Bleeding and Bleeding Disorders YEWSAVIN INC (US) 2026-01-15 — — US disclosed
US-12343317-B2 Compositions and methods for treating bleeding and bleeding disorders YewSavin, Inc. (US) 2025-07-01 — — US disclosed
WO-2024233598-A1 COMPOSITIONS AND METHODS FOR TREATING BLEEDING AND BLEEDING DISORDERS YewSavin, Inc. (US) 2024-11-14 — — WO disclosed
EP-4429763-A1 COMPOSITIONS AND METHODS FOR TREATING BLEEDING AND BLEEDING DISORDERS Yewsavin, Inc. (US) 2024-09-18 — — EP disclosed
US-20230190679-A1 COMPOSITIONS AND METHODS FOR TREATING BLEEDING AND BLEEDING DISORDERS YewSavin, Inc. (US) 2023-06-22 — — US disclosed
WO-2023086388-A1 COMPOSITIONS AND METHODS FOR TREATING BLEEDING AND BLEEDING DISORDERS YewSavin, Inc. (US) 2023-05-19 — — WO disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20260014100-A1 Compositions and Methods for Treating Bleeding and Bleeding Disorders SERPINC1, F2, F13B TUBB1 3042/4885CTSL 357/4885MEN1 3367/4885
US-20230190679-A1 COMPOSITIONS AND METHODS FOR TREATING BLEEDING AND BLEEDING DISORDERS SERPINC1, SERPINE1, SERPINH1 TUBB1 2558/4885CTSL 310/4885MEN1 2457/4885
US-12343317-B2 Compositions and methods for treating bleeding and bleeding disorders SERPINC1, SERPINE1, SERPINH1 TUBB1 2558/4885CTSL 310/4885MEN1 2457/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.

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