SCHEMBL25199496

SCHEMBL25199496

CC(C)(C)OC(=O)N1CCC(n2cc3cc(Cl)nc(Cl)c3n2)CC1

nearest known ligand 0.41

Predicted protein targets (top 10)

geneUniProtsupporting neighboursconfidence
DDB1 Q16531 1/20 0.41
CRBN Q96SW2 1/20 0.41
STS P08842 4/20 0.41
GPR119 Q8TDV5 7/20 0.41
KDM4E B2RXH2 1/20 0.41
MAPT P10636 1/20 0.41
THRB P10828 1/20 0.41
MET P08581 1/20 0.40
IRAK4 Q9NWZ3 1/20 0.40
POLB P06746 1/20 0.39

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL25200960 0.83 DDB1 (0.40) DDB1CRBNSTSGPR119KDM4E
SCHEMBL25219348 0.82 DDB1 (0.40) DDB1CRBNSTSGPR119KDM4E
SCHEMBL25198469 0.82 MET (0.43) DDB1CRBNSTSGPR119KDM4E
SCHEMBL20134927 0.81 TLR8 (0.46) DDB1CRBNGPR119KDM4EMAPT
SCHEMBL25204297 0.81 NSD2 (0.42) DDB1CRBNSTSKDM4EMET
SCHEMBL25210013 0.81 GPR119 (0.45) STSGPR119THRB
SCHEMBL24779560 0.79 TP53 (0.44) DDB1CRBNSTSGPR119MAPT
SCHEMBL31356908 0.79 RECQL (0.43) DDB1CRBNSTSGPR119MAPT
SCHEMBL25197622 0.79 DPP4 (0.44) DDB1CRBNGPR119KDM4EMAPT
SCHEMBL28549250 0.79 CTSD (0.41) DDB1CRBNGPR119KDM4EMAPT

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-20250082633-A1 COMPOUNDS AND METHODS FOR MODULATING SPLICING REMIX THERAPEUTICS INC (US) 2025-03-13 US disclosed
EP-4436961-A1 COMPOUNDS AND METHODS FOR MODULATING SPLICING Remix Therapeutics Inc. (US) 2024-10-02 EP disclosed
WO-2023097007-A1 COMPOUNDS AND METHODS FOR MODULATING SPLICING REMIX THERAPEUTICS INC. (US) 2023-06-01 WO disclosed
WO-2023097007-A1 COMPOUNDS AND METHODS FOR MODULATING SPLICING REMIX THERAPEUTICS INC. (US) 2023-06-01 WO disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20250082633-A1 COMPOUNDS AND METHODS FOR MODULATING SPLICING RBM17, SNRPA, SNRPA1 DDB1 151/4885CRBN 964/4885STS 3350/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.