SCHEMBL25219348

SCHEMBL25219348

CC(C)(C)OC(=O)N1CCC(n2cc3nc(Cl)cc(Br)c3n2)CC1

nearest known ligand 0.40

Predicted protein targets (top 18)

geneUniProtsupporting neighboursconfidence
DDB1 Q16531 1/20 0.40
CRBN Q96SW2 1/20 0.40
STS P08842 4/20 0.39
CNR1 P21554 1/20 0.39
GPR119 Q8TDV5 3/20 0.39
KDM4E B2RXH2 1/20 0.39
MAPT P10636 1/20 0.39
THRB P10828 1/20 0.39
MET P08581 1/20 0.39
NR3C1 P04150 2/20 0.39
IRAK4 Q9NWZ3 1/20 0.38
MEN1 O00255 2/20 0.38
KMT2A Q03164 2/20 0.38
USP2 O75604 1/20 0.38
HPGD P15428 1/20 0.38
NPSR1 Q6W5P4 1/20 0.38
HSD17B10 Q99714 1/20 0.38
HCAR1 Q9BXC0 1/20 0.38

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL25200960 0.89 DDB1 (0.40) DDB1CRBNSTSGPR119KDM4E
SCHEMBL25204297 0.87 NSD2 (0.42) DDB1CRBNSTSKDM4EMET
SCHEMBL25222564 0.84 JAK2 (0.32)
SCHEMBL25199496 0.82 DDB1 (0.41) DDB1CRBNSTSGPR119KDM4E
SCHEMBL25198478 0.81 HCAR1 (0.44) DDB1CRBNSTSCNR1GPR119
SCHEMBL28549250 0.80 CTSD (0.41) DDB1CRBNGPR119KDM4EMAPT
SCHEMBL22532431 0.80 DDB1 (0.45) DDB1CRBNSTSGPR119KDM4E
SCHEMBL20134846 0.78 CNR1 (0.47) STSCNR1GPR119MAPTNR3C1
SCHEMBL28560044 0.77 KCNH2 (0.45) DDB1CRBNSTSGPR119KDM4E
SCHEMBL25198469 0.77 MET (0.43) DDB1CRBNSTSGPR119KDM4E

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-20250082633-A1 COMPOUNDS AND METHODS FOR MODULATING SPLICING REMIX THERAPEUTICS INC (US) 2025-03-13 US disclosed
EP-4436961-A1 COMPOUNDS AND METHODS FOR MODULATING SPLICING Remix Therapeutics Inc. (US) 2024-10-02 EP disclosed
WO-2023097007-A1 COMPOUNDS AND METHODS FOR MODULATING SPLICING REMIX THERAPEUTICS INC. (US) 2023-06-01 WO disclosed
WO-2023097007-A1 COMPOUNDS AND METHODS FOR MODULATING SPLICING REMIX THERAPEUTICS INC. (US) 2023-06-01 WO disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20250082633-A1 COMPOUNDS AND METHODS FOR MODULATING SPLICING RBM17, SNRPA, SNRPA1 DDB1 151/4885CRBN 964/4885STS 3350/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.