SCHEMBL25199608

SCHEMBL25199608

CS(=O)(=O)Nc1ccc(C(=O)/C=C\c2ccc(C(=O)O)cc2)cc1

nearest known ligand 0.58

Predicted protein targets (top 19)

geneUniProtsupporting neighboursconfidence
XDH P47989 1/20 0.57
ESR1 P03372 1/20 0.55
MAPT P10636 3/20 0.52
KMT2A Q03164 2/20 0.52
MAPK1 P28482 2/20 0.52
MAOB P27338 1/20 0.52
MEN1 O00255 1/20 0.52
NPC1 O15118 1/20 0.52
RAB9A P51151 1/20 0.52
TP53 P04637 1/20 0.51
CYP3A4 P08684 1/20 0.51
ALOX15 P16050 1/20 0.51
BLM P54132 1/20 0.51
CASP7 P55210 1/20 0.51
SMN1; SMN2 Q16637 1/20 0.51
HSD17B10 Q99714 1/20 0.51
TDP1 Q9NUW8 1/20 0.51
PADI4 Q9UM07 1/20 0.49
F3 P13726 1/20 0.49

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL25232308 1.00 XDH (0.57) XDHESR1MAPTKMT2AMAPK1
SCHEMBL25422136 1.00 XDH (0.57) XDHESR1MAPTKMT2AMAPK1
SCHEMBL3483602 0.89 F3 (0.66) XDHESR1MAPTKMT2AMAOB
SCHEMBL3483600 0.89 F3 (0.66) XDHESR1MAPTKMT2AMAOB
SCHEMBL118340 0.83 KEAP1 (0.59) KMT2ASMN1; SMN2
SCHEMBL3483669 0.82 MAPT (0.62) MAPTKMT2AMAPK1MEN1
SCHEMBL3483672 0.82 MAPT (0.62) MAPTKMT2AMAPK1MEN1
SCHEMBL25219825 0.82 HDAC4 (0.67) MAPTKMT2AMEN1SMN1; SMN2
SCHEMBL7747780 0.82 ESR1 (0.66) ESR1MAPK1PADI4
SCHEMBL7747783 0.82 ESR1 (0.66) ESR1MAPK1PADI4

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-20260014100-A1 Compositions and Methods for Treating Bleeding and Bleeding Disorders YEWSAVIN INC (US) 2026-01-15 US disclosed
US-12343317-B2 Compositions and methods for treating bleeding and bleeding disorders YewSavin, Inc. (US) 2025-07-01 US disclosed
WO-2024233598-A1 COMPOSITIONS AND METHODS FOR TREATING BLEEDING AND BLEEDING DISORDERS YewSavin, Inc. (US) 2024-11-14 WO disclosed
EP-4429763-A1 COMPOSITIONS AND METHODS FOR TREATING BLEEDING AND BLEEDING DISORDERS Yewsavin, Inc. (US) 2024-09-18 EP disclosed
US-20230190679-A1 COMPOSITIONS AND METHODS FOR TREATING BLEEDING AND BLEEDING DISORDERS YewSavin, Inc. (US) 2023-06-22 US disclosed
WO-2023086388-A1 COMPOSITIONS AND METHODS FOR TREATING BLEEDING AND BLEEDING DISORDERS YewSavin, Inc. (US) 2023-05-19 WO disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20260014100-A1 Compositions and Methods for Treating Bleeding and Bleeding Disorders SERPINC1, F2, F13B XDH 1328/4885ESR1 2661/4885MAPT 3297/4885
US-20230190679-A1 COMPOSITIONS AND METHODS FOR TREATING BLEEDING AND BLEEDING DISORDERS SERPINC1, SERPINE1, SERPINH1 XDH 1963/4885ESR1 3467/4885MAPT 3512/4885
US-12343317-B2 Compositions and methods for treating bleeding and bleeding disorders SERPINC1, SERPINE1, SERPINH1 XDH 1963/4885ESR1 3467/4885MAPT 3512/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.