SCHEMBL7747783

SCHEMBL7747783

CS(=O)(=O)Nc1ccc(C=CC(=O)O)cc1

nearest known ligand 0.66

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
ESR1 P03372 2/20 0.66
PKM P14618 2/20 0.52
HCAR2 Q8TDS4 2/20 0.52
CA12 O43570 1/20 0.52
AKR1B10 O60218 1/20 0.52
CA1 P00915 1/20 0.52
CA2 P00918 1/20 0.52
CA3 P07451 1/20 0.52
TYR P14679 1/20 0.52
AKR1B1 P15121 1/20 0.52
CA4 P22748 1/20 0.52
CA6 P23280 1/20 0.52
DPP4 P27487 1/20 0.52
CA5A P35218 1/20 0.52
CA7 P43166 1/20 0.52
CA9 Q16790 1/20 0.52
ESR2 Q92731 1/20 0.52
CA14 Q9ULX7 1/20 0.52
CA5B Q9Y2D0 1/20 0.52
HDAC1 Q13547 5/20 0.50

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL7747780 1.00 ESR1 (0.66) ESR1PKMHCAR2CA12AKR1B10
SCHEMBL14358816 0.83 KEAP1 (0.58) ESR1CA12CA1CA2CA9
SCHEMBL14358814 0.83 KEAP1 (0.58) ESR1CA12CA1CA2CA9
SCHEMBL25199608 0.82 XDH (0.57) ESR1MAPK1PADI4
SCHEMBL25422136 0.82 XDH (0.57) ESR1MAPK1PADI4
SCHEMBL25232308 0.82 XDH (0.57) ESR1MAPK1PADI4
SCHEMBL15218448 0.80 KEAP1 (0.67) ESR1PKMCA12CA1CA2
SCHEMBL19177038 0.79 MAPK1 (0.54) ESR1PKMHCAR2CA12AKR1B10
SCHEMBL2690712 0.79 HDAC1 (0.78) ESR1PKMHDAC1HDAC4HDAC8
SCHEMBL2690711 0.79 HDAC1 (0.78) ESR1PKMHDAC1HDAC4HDAC8

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 14 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-10294125-B2 Filter medium, method for producing filter medium, water treatment module, and water treatment device MITSUBISHI MATERIALS CORPORATION (JP) 2019-05-21 US disclosed
US-10208210-B2 Hydrophilic oil repellent and production method of same, surface coating material, coating film, resin composition, oil-water separation filter material, and porous body MITSUBISHI MATERIALS CORPORATION (JP) 2019-02-19 US disclosed
US-20170247265-A1 FILTER MEDIUM, METHOD FOR PRODUCING FILTER MEDIUM, WATER TREATMENT MODULE, AND WATER TREATMENT DEVICE MITSUBISHI MATERIALS CORPORATION (JP) 2017-08-31 US disclosed
US-20170210912-A1 HYDROPHILIC OIL REPELLENT AND PRODUCTION METHOD OF SAME, SURFACE COATING MATERIAL, COATING FILM, RESIN COMPOSITION, OIL-WATER SEPARATION FILTER MATERIAL, AND POROUS BODY MITSUBISHI MATERIALS ELECTRONIC CHEMICALS CO., LTD. (JP) 2017-07-27 US disclosed
EP-0622361-B1 Heterocyclic compounds as bradykinin antagonists FUJISAWA PHARMACEUTICAL CO (JP) 2001-10-04 EP disclosed
US-6169095-B1 FOR PREVENTION AND/OR TREATMENT OF BRADYKININ OR ITS ANALOGUES MEDIATED DISEASES IN THE EYE, SUCH AS ALLERGY, INFLAMMATION AND PAIN OF THE EYE FUJISAWA PHARMACEUTICAL CO., LTD. (JP) 2001-01-02 US disclosed
US-5922711-A ANTIALLERGENS, ANTIINFLAMMATORY AGENTS, AUTOIMMUNE DISEASES, SHOCK OR ANALGESICS FUJISAWA PHARMACEUTICAL CO., LTD. (JP) 1999-07-13 US disclosed
EP-0596406-B1 Imidazo (1,2-a) Pyridines as bradykinin antagonists FUJISAWA PHARMACEUTICAL CO (JP) 1998-12-16 EP disclosed
US-5750699-A HALOGENATING OF CORRESPONDING COMPOUND FUJISAWA PHARMACEUTICAL CO., LTD. (JP) 1998-05-12 US disclosed
US-5708173-A PREPARATION OF SUBSTITUTED QUINOLINE COMPOUNDS FUJISAWA PHARMACEUTICAL CO., LTD. (JP) 1998-01-13 US disclosed
US-5574042-A ANTAGONIST FOR BRADYKININS AS ANTIALLERGENS, AUTOIMMUNE DISEASES, ANTIINFLAMMATORY AGENTS, SHOCK OR PAIN FUJISAWA PHARMACEUTICAL CO., LTD (JP) 1996-11-12 US disclosed
US-5563162-A CAN BE ADMINISTERD FOR THE TREATMENT OF ALLERGY, INFLAMMATION, AUTOIMMUNE DISEASES, SHOCK OR PAIN IN ANIMALS AND HUMANS FUJISAWA PHARMACEUTICAL CO., LTD. (JP) 1996-10-08 US disclosed
EP-0622361-A1 Heterocyclic compounds as bradykinin antagonists FUJISAWA PHARMACEUTICAL CO., LTD. (JP) 1994-11-02 EP disclosed
EP-0596406-A1 Imidazo (1,2-a) Pyridines as bradykinin antagonists FUJISAWA PHARMACEUTICAL CO., LTD. (JP) 1994-05-11 EP disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20170210912-A1 HYDROPHILIC OIL REPELLENT AND PRODUCTION METHOD OF SAME, SURFACE COATING MATERIAL, COATING FILM, RESIN COMPOSITION, OIL-WATER SEPARATION FILTER MATERIAL, AND POROUS BODY FABP4, FFAR1, FFAR2 ESR1 252/4885PKM 4280/4885HCAR2 557/4885
US-10294125-B2 Filter medium, method for producing filter medium, water treatment module, and water treatment device AQP1, NEFM, AQP4 ESR1 2608/4885PKM 1265/4885HCAR2 1025/4885
US-10208210-B2 Hydrophilic oil repellent and production method of same, surface coating material, coating film, resin composition, oil-water separation filter material, and porous body FABP4, FFAR1, FFAR2 ESR1 252/4885PKM 4280/4885HCAR2 557/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.