SCHEMBL25201255

SCHEMBL25201255

O=C(O)c1ccc(/C=C/C(=O)c2ccc(N3C(=O)C=CC3=O)cc2)cc1

nearest known ligand 0.68

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
DDAH1 O94760 1/20 0.68
MAPT P10636 5/20 0.60
KMT2A Q03164 3/20 0.60
MEN1 O00255 2/20 0.60
ALDH1A1 P00352 2/20 0.60
NPSR1 Q6W5P4 1/20 0.60
XDH P47989 1/20 0.55
F3 P13726 1/20 0.50
SMN1; SMN2 Q16637 2/20 0.49
CYP3A4 P08684 2/20 0.49
TP53 P04637 1/20 0.49
ALOX15 P16050 1/20 0.49
MAPK1 P28482 1/20 0.49
BLM P54132 1/20 0.49
CASP7 P55210 1/20 0.49
HSD17B10 Q99714 1/20 0.49
TDP1 Q9NUW8 1/20 0.49
TNFRSF1A P19438 2/20 0.49
CA1 P00915 3/20 0.48
CA2 P00918 3/20 0.48

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL20582227 0.90 CYP1B1 (0.62) DDAH1MAPTKMT2AMEN1ALDH1A1
SCHEMBL20582226 0.90 CYP1B1 (0.62) DDAH1MAPTKMT2AMEN1ALDH1A1
SCHEMBL3006657 0.82 MGLL (0.60) MAPTKMT2AMEN1ALDH1A1NPSR1
SCHEMBL3000236 0.82 MAPT (0.54) MAPTKMT2AMEN1ALDH1A1NPSR1
SCHEMBL3006662 0.82 MGLL (0.60) MAPTKMT2AMEN1ALDH1A1NPSR1
SCHEMBL3000241 0.82 MAPT (0.54) MAPTKMT2AMEN1ALDH1A1NPSR1
SCHEMBL25195971 0.82 XDH (0.74) MAPTKMT2AMEN1ALDH1A1XDH
SCHEMBL25201250 0.82 XDH (0.74) MAPTKMT2AMEN1ALDH1A1XDH
SCHEMBL2997293 0.82 XDH (0.74) MAPTKMT2AMEN1ALDH1A1XDH
SCHEMBL2997295 0.82 XDH (0.74) MAPTKMT2AMEN1ALDH1A1XDH

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-20260014100-A1 Compositions and Methods for Treating Bleeding and Bleeding Disorders YEWSAVIN INC (US) 2026-01-15 US disclosed
US-12343317-B2 Compositions and methods for treating bleeding and bleeding disorders YewSavin, Inc. (US) 2025-07-01 US disclosed
WO-2024233598-A1 COMPOSITIONS AND METHODS FOR TREATING BLEEDING AND BLEEDING DISORDERS YewSavin, Inc. (US) 2024-11-14 WO disclosed
EP-4429763-A1 COMPOSITIONS AND METHODS FOR TREATING BLEEDING AND BLEEDING DISORDERS Yewsavin, Inc. (US) 2024-09-18 EP disclosed
US-20230190679-A1 COMPOSITIONS AND METHODS FOR TREATING BLEEDING AND BLEEDING DISORDERS YewSavin, Inc. (US) 2023-06-22 US disclosed
WO-2023086388-A1 COMPOSITIONS AND METHODS FOR TREATING BLEEDING AND BLEEDING DISORDERS YewSavin, Inc. (US) 2023-05-19 WO disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20260014100-A1 Compositions and Methods for Treating Bleeding and Bleeding Disorders SERPINC1, F2, F13B DDAH1 4413/4885MAPT 3297/4885KMT2A 2792/4885
US-20230190679-A1 COMPOSITIONS AND METHODS FOR TREATING BLEEDING AND BLEEDING DISORDERS SERPINC1, SERPINE1, SERPINH1 DDAH1 3688/4885MAPT 3512/4885KMT2A 3188/4885
US-12343317-B2 Compositions and methods for treating bleeding and bleeding disorders SERPINC1, SERPINE1, SERPINH1 DDAH1 3688/4885MAPT 3512/4885KMT2A 3188/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.