SCHEMBL25207556

SCHEMBL25207556

COc1cc(/C=C/C(=O)c2ccc(O)cc2)ccc1OCC(=O)N1CCOCC1

nearest known ligand 0.68

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
▸ ALDH1A1 P00352 5/20 0.68
▸ KDM4E B2RXH2 8/20 0.66
▸ LMNA P02545 4/20 0.66
▸ MAPT P10636 4/20 0.66
▸ GAA P10253 2/20 0.61
▸ MEN1 O00255 4/20 0.60
▸ KMT2A Q03164 4/20 0.60
▸ KEAP1 Q14145 1/20 0.59
▸ NFE2L2 Q16236 1/20 0.59
▸ HPGD P15428 2/20 0.58
▸ HSD17B10 Q99714 1/20 0.58
▸ SMN1; SMN2 Q16637 2/20 0.58
▸ APP P05067 1/20 0.58
▸ CTSL P07711 1/20 0.56
▸ RECQL P46063 1/20 0.55
▸ ABCG2 Q9UNQ0 1/20 0.55
▸ MITF O75030 1/20 0.55
▸ MAPK1 P28482 1/20 0.55
▸ HTT P42858 1/20 0.55
▸ CACNA1B Q00975 1/20 0.55

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL30383954 0.86 KEAP1 (0.69) ALDH1A1KDM4ELMNAMAPTGAA
SCHEMBL25223384 0.86 KEAP1 (0.69) ALDH1A1KDM4ELMNAMAPTGAA
SCHEMBL25198003 0.86 KEAP1 (0.69) ALDH1A1KDM4ELMNAMAPTGAA
SCHEMBL25189629 0.83 KEAP1 (0.67) ALDH1A1KDM4ELMNAMAPTKMT2A
SCHEMBL25212469 0.83 KEAP1 (0.67) ALDH1A1KDM4ELMNAMAPTKMT2A
SCHEMBL25206771 0.82 MAPT (0.58) ALDH1A1KDM4ELMNAMAPTMEN1
SCHEMBL25188980 0.81 LMNA (0.72) ALDH1A1KDM4ELMNAMAPTMEN1
SCHEMBL31428602 0.81 ALDH1A1 (1.00) ALDH1A1KDM4ELMNAMAPTGAA
SCHEMBL5692309 0.81 ALDH1A1 (1.00) ALDH1A1KDM4ELMNAMAPTGAA
SCHEMBL25200519 0.79 MAPT (1.00) ALDH1A1KDM4ELMNAMAPTGAA

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-20260014100-A1 Compositions and Methods for Treating Bleeding and Bleeding Disorders YEWSAVIN INC (US) 2026-01-15 — — US disclosed
US-12343317-B2 Compositions and methods for treating bleeding and bleeding disorders YewSavin, Inc. (US) 2025-07-01 — — US disclosed
WO-2024233598-A1 COMPOSITIONS AND METHODS FOR TREATING BLEEDING AND BLEEDING DISORDERS YewSavin, Inc. (US) 2024-11-14 — — WO disclosed
EP-4429763-A1 COMPOSITIONS AND METHODS FOR TREATING BLEEDING AND BLEEDING DISORDERS Yewsavin, Inc. (US) 2024-09-18 — — EP disclosed
US-20230190679-A1 COMPOSITIONS AND METHODS FOR TREATING BLEEDING AND BLEEDING DISORDERS YewSavin, Inc. (US) 2023-06-22 — — US disclosed
WO-2023086388-A1 COMPOSITIONS AND METHODS FOR TREATING BLEEDING AND BLEEDING DISORDERS YewSavin, Inc. (US) 2023-05-19 — — WO disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20260014100-A1 Compositions and Methods for Treating Bleeding and Bleeding Disorders SERPINC1, F2, F13B ALDH1A1 3285/4885KDM4E 1732/4885LMNA 1180/4885
US-20230190679-A1 COMPOSITIONS AND METHODS FOR TREATING BLEEDING AND BLEEDING DISORDERS SERPINC1, SERPINE1, SERPINH1 ALDH1A1 3081/4885KDM4E 2652/4885LMNA 1817/4885
US-12343317-B2 Compositions and methods for treating bleeding and bleeding disorders SERPINC1, SERPINE1, SERPINH1 ALDH1A1 3081/4885KDM4E 2652/4885LMNA 1817/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.

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