Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CNR1 | P21554 | 3/20 | 0.41 |
| ▸ | MAP2K1 | Q02750 | 1/20 | 0.35 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.33 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.33 |
| ▸ | HTR2A | P28223 | 1/20 | 0.33 |
| ▸ | HCRTR1 | O43613 | 5/20 | 0.32 |
| ▸ | HCRTR2 | O43614 | 5/20 | 0.32 |
| ▸ | ACACB | O00763 | 1/20 | 0.32 |
| ▸ | NOS1 | P29475 | 1/20 | 0.31 |
| ▸ | NOS2 | P35228 | 1/20 | 0.31 |
| ▸ | GABRA1 | P14867 | 1/20 | 0.31 |
| ▸ | GABRB2 | P47870 | 1/20 | 0.31 |
| ▸ | ADRA2A | P08913 | 1/20 | 0.31 |
| ▸ | ADRA2B | P18089 | 1/20 | 0.31 |
| ▸ | ADRA2C | P18825 | 1/20 | 0.31 |
| ▸ | AOC3 | Q16853 | 1/20 | 0.31 |
| ▸ | ESR1 | P03372 | 1/20 | 0.31 |
| ▸ | ESR2 | Q92731 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL15761511 | 0.85 | CNR1 (0.42) | CNR1MAP2K1ALDH1A1HCRTR1HCRTR2 | |
| SCHEMBL11621298 | 0.79 | NCF1 (0.43) | CNR1ALDH1A1CYP3A4ACACB | |
| SCHEMBL9447425 | 0.78 | CCR1 (0.48) | CNR1ALDH1A1NOS1NOS2 | |
| SCHEMBL25277344 | 0.77 | CYP3A4 (0.41) | CYP3A4ACACB | |
| SCHEMBL3276573 | 0.76 | NOS1 (0.40) | CNR1NOS1NOS2 | |
| SCHEMBL16114069 | 0.76 | CNR1 (0.44) | CNR1ALDH1A1CYP3A4NOS1NOS2 | |
| SCHEMBL1110998 | 0.76 | HTR7 (0.42) | CNR1HTR2AHCRTR1HCRTR2NOS1 | |
| SCHEMBL29956257 | 0.76 | CNR1 (0.39) | CNR1MAP2K1HCRTR1HCRTR2ACACB | |
| SCHEMBL30440725 | 0.75 | CNR1 (0.37) | CNR1HCRTR1HCRTR2 | |
| SCHEMBL19065189 | 0.74 | KDM4E (0.53) | CNR1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20250066377-A1 | AMINO CHROMEN-2-ONE MODULATORS OF POLRMT | PRETZEL THERAPEUTICS, INC. (US) | 2025-02-27 | — | — | US | disclosed |
| WO-2023114539-A1 | AMINO CHROMEN-2-ONE MODULATORS OF POLRMT | PRETZEL THERAPEUTICS, INC. (US) | 2023-06-22 | — | — | WO | disclosed |
| WO-2023114539-A1 | AMINO CHROMEN-2-ONE MODULATORS OF POLRMT | PRETZEL THERAPEUTICS, INC. (US) | 2023-06-22 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20250066377-A1 | AMINO CHROMEN-2-ONE MODULATORS OF POLRMT | POLRMT, TFAM, POLM | CNR1 3898/4885MAP2K1 3442/4885ALDH1A1 3192/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.