Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NR1H4 | Q96RI1 | 2/20 | 0.47 |
| ▸ | MRGPRX4 | Q96LA9 | 4/20 | 0.40 |
| ▸ | CTSA | P10619 | 1/20 | 0.40 |
| ▸ | S1PR5 | Q9H228 | 1/20 | 0.38 |
| ▸ | ERN1 | O75460 | 1/20 | 0.38 |
| ▸ | EGFR | P00533 | 3/20 | 0.37 |
| ▸ | ERBB2 | P04626 | 3/20 | 0.37 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.36 |
| ▸ | HPGD | P15428 | 2/20 | 0.36 |
| ▸ | HTT | P42858 | 2/20 | 0.36 |
| ▸ | NPC1 | O15118 | 1/20 | 0.36 |
| ▸ | MAPT | P10636 | 1/20 | 0.36 |
| ▸ | RAB9A | P51151 | 1/20 | 0.36 |
| ▸ | MDM2 | Q00987 | 1/20 | 0.36 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.36 |
| ▸ | GPR55 | Q9Y2T6 | 1/20 | 0.36 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.36 |
| ▸ | LMNA | P02545 | 1/20 | 0.36 |
| ▸ | TSHR | P16473 | 1/20 | 0.36 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2522702 | 0.86 | MRGPRX4 (0.43) | NR1H4MRGPRX4CTSAS1PR5ERN1 | |
| SCHEMBL2520431 | 0.86 | NR1H4 (0.42) | NR1H4MRGPRX4CTSAS1PR5ERN1 | |
| SCHEMBL2520424 | 0.86 | NR1H4 (0.42) | NR1H4MRGPRX4CTSAS1PR5ERN1 | |
| SCHEMBL2519287 | 0.84 | ALOX5 (0.44) | L3MBTL1LMNA | |
| SCHEMBL2519288 | 0.84 | ALOX5 (0.44) | L3MBTL1LMNA | |
| SCHEMBL2522249 | 0.81 | DGAT1 (0.53) | NR1H4MRGPRX4CTSAS1PR5ERN1 | |
| SCHEMBL12208443 | 0.75 | NR1H4 (0.35) | NR1H4TSHR | |
| SCHEMBL2521362 | 0.74 | ALDH1A1 (0.37) | NR1H4ALDH1A1HPGDNPC1RAB9A | |
| SCHEMBL17769265 | 0.72 | S1PR5 (0.43) | MRGPRX4CTSAS1PR5ERN1ALDH1A1 | |
| SCHEMBL372389 | 0.71 | S1PR5 (0.48) | MRGPRX4S1PR5ERN1ALDH1A1HPGD |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20110251173-A1 | CHEMICAL COMPOUNDS | ASTRAZENECA AB (SE) | 2011-10-13 | — | — | US | disclosed |
| US-20110251173-A1 | CHEMICAL COMPOUNDS | ASTRAZENECA AB (SE) | 2011-10-13 | — | — | US | disclosed |
| US-20110251173-A1 | CHEMICAL COMPOUNDS | ASTRAZENECA AB (SE) | 2011-10-13 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20110251173-A1 | CHEMICAL COMPOUNDS | DGAT1, DGAT2, SLC5A1 | NR1H4 582/4885MRGPRX4 415/4885CTSA 2287/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.