Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MGLL | Q99685 | 1/20 | 0.41 |
| ▸ | PDE3B | Q13370 | 1/20 | 0.38 |
| ▸ | PDE3A | Q14432 | 1/20 | 0.38 |
| ▸ | NR4A2 | P43354 | 1/20 | 0.36 |
| ▸ | DHODH | Q02127 | 1/20 | 0.36 |
| ▸ | POLQ | O75417 | 1/20 | 0.35 |
| ▸ | CNR1 | P21554 | 1/20 | 0.35 |
| ▸ | SCN8A | Q9UQD0 | 4/20 | 0.35 |
| ▸ | SCN10A | Q9Y5Y9 | 4/20 | 0.35 |
| ▸ | EGLN1 | Q9GZT9 | 4/20 | 0.34 |
| ▸ | PRKAG1 | P54619 | 1/20 | 0.34 |
| ▸ | PRKAA1 | Q13131 | 1/20 | 0.34 |
| ▸ | PRKAB1 | Q9Y478 | 1/20 | 0.34 |
| ▸ | CYP46A1 | Q9Y6A2 | 1/20 | 0.34 |
| ▸ | SORT1 | Q99523 | 1/20 | 0.34 |
| ▸ | LRRK2 | Q5S007 | 1/20 | 0.33 |
| ▸ | DYRK1A | Q13627 | 1/20 | 0.33 |
| ▸ | ALDH2 | P05091 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL25281510 | 0.86 | CNR1 (0.43) | PDE3BPDE3ANR4A2DHODHCNR1 | |
| SCHEMBL31055668 | 0.81 | MGLL (0.48) | MGLLSCN8ASCN10ADYRK1AALDH2 | |
| SCHEMBL25232491 | 0.77 | PRKAG1 (0.49) | MGLLPDE3BPDE3APRKAG1PRKAA1 | |
| SCHEMBL25276173 | 0.77 | PRKAG1 (0.49) | MGLLPDE3BPDE3APRKAG1PRKAA1 | |
| SCHEMBL22866621 | 0.74 | CYP46A1 (0.40) | PDE3BPDE3ANR4A2DHODHCNR1 | |
| SCHEMBL31055692 | 0.72 | PRKAG1 (0.46) | PDE3BPDE3APOLQPRKAG1PRKAA1 | |
| SCHEMBL25276617 | 0.72 | PRKAG1 (0.46) | PDE3BPDE3APOLQPRKAG1PRKAA1 | |
| SCHEMBL19892431 | 0.72 | MAPK14 (0.40) | PDE3BPDE3ANR4A2DHODHPOLQ | |
| SCHEMBL29628231 | 0.70 | SLC6A3 (0.46) | NR4A2POLQALDH2 | |
| SCHEMBL22867141 | 0.69 | NLRP3 (0.41) | PDE3BPDE3ANR4A2DHODHCNR1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2023110958-A1 | BICYCLIC HETEROCYCLIC COMPOUNDS USEFUL AS MONOACYLGLYCEROL LIPASE INHIBITORS | F. HOFFMANN-LA ROCHE AG (CH) | 2023-06-22 | — | — | WO | disclosed |