Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.41 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.41 |
| ▸ | GABRG2 | P18507 | 1/20 | 0.37 |
| ▸ | GABRB3 | P28472 | 1/20 | 0.37 |
| ▸ | GABRA5 | P31644 | 1/20 | 0.37 |
| ▸ | F2 | P00734 | 1/20 | 0.37 |
| ▸ | GLA | P06280 | 1/20 | 0.37 |
| ▸ | HPGD | P15428 | 1/20 | 0.37 |
| ▸ | KDR | P35968 | 2/20 | 0.37 |
| ▸ | BRD4 | O60885 | 2/20 | 0.37 |
| ▸ | PIK3CD | O00329 | 1/20 | 0.37 |
| ▸ | ABL1 | P00519 | 1/20 | 0.37 |
| ▸ | EGFR | P00533 | 1/20 | 0.37 |
| ▸ | HCK | P08631 | 1/20 | 0.37 |
| ▸ | SRC | P12931 | 1/20 | 0.37 |
| ▸ | PIK3CA | P42336 | 1/20 | 0.37 |
| ▸ | PIK3CB | P42338 | 1/20 | 0.37 |
| ▸ | MTOR | P42345 | 1/20 | 0.37 |
| ▸ | PIK3CG | P48736 | 1/20 | 0.37 |
| ▸ | EPHB4 | P54760 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL20483115 | 0.83 | KDM4E (0.39) | ALDH1A1KDM4EGABRG2GABRB3GABRA5 | |
| SCHEMBL25909811 | 0.83 | HSP90AA1 (0.41) | ALDH1A1KDM4EGABRG2GABRB3GABRA5 | |
| SCHEMBL27361311 | 0.82 | MET (0.46) | ALDH1A1KDM4EGABRG2GABRB3GABRA5 | |
| SCHEMBL22158223 | 0.82 | ALDH1A1 (0.41) | ALDH1A1F2GLAHPGDHPGDS | |
| SCHEMBL31194316 | 0.82 | MET (0.43) | ALDH1A1KDM4EGABRG2GABRB3GABRA5 | |
| SCHEMBL31194282 | 0.81 | GABRG2 (0.39) | ALDH1A1KDM4EGABRG2GABRB3GABRA5 | |
| SCHEMBL25702072 | 0.80 | APP (0.39) | ALDH1A1KDM4EHPGDPDE10AMAPT | |
| SCHEMBL23347080 | 0.79 | KDR (0.39) | ALDH1A1F2GLAHPGDKDR | |
| SCHEMBL19707129 | 0.79 | MET (0.39) | ALDH1A1KDM4EGABRG2GABRB3GABRA5 | |
| SCHEMBL29650289 | 0.79 | MET (0.39) | ALDH1A1KDM4EGABRG2GABRB3GABRA5 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-4448105-A1 | HETEROCYCLE DERIVATIVES FOR THE TREATMENT OF DISEASE | VIR Biotechnology, Inc. (US) | 2024-10-23 | — | — | EP | disclosed |
| WO-2023114428-A1 | HETEROCYCLE DERIVATIVES FOR THE TREATMENT OF DISEASE | Vir Biotechnology, Inc. (US) | 2023-06-22 | — | — | WO | disclosed |
| WO-2023114428-A1 | HETEROCYCLE DERIVATIVES FOR THE TREATMENT OF DISEASE | Vir Biotechnology, Inc. (US) | 2023-06-22 | — | — | WO | disclosed |