Sugi Predict

Sugi Predict / Compounds / SCHEMBL2523630

SCHEMBL2523630

SCHEMBL2523630

Fc1ccc(-c2cc3n(n2)CCOC3)cc1

nearest known ligand 0.47

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
▸ TSHR P16473 4/20 0.47
▸ KDM4E B2RXH2 6/20 0.45
▸ HPGD P15428 5/20 0.45
▸ ALDH1A1 P00352 4/20 0.45
▸ HSD17B10 Q99714 4/20 0.45
▸ NPSR1 Q6W5P4 3/20 0.45
▸ KMT2A Q03164 2/20 0.45
▸ RAB9A P51151 5/20 0.43
▸ NPC1 O15118 4/20 0.43
▸ AR P10275 1/20 0.43
▸ MAPT P10636 3/20 0.42
▸ HTT P42858 2/20 0.42
▸ LMNA P02545 2/20 0.42
▸ ALOX15 P16050 1/20 0.42
▸ USP2 O75604 1/20 0.40
▸ TP53 P04637 1/20 0.40
▸ GLA P06280 1/20 0.40
▸ CASP1 P29466 1/20 0.40
▸ POLB P06746 1/20 0.39
▸ PRKDC P78527 1/20 0.39

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL25227540 0.91 TSHR (0.43) TSHRKDM4EHPGDALDH1A1HSD17B10
SCHEMBL22768039 0.84 GRM5 (0.48) TSHRKDM4EHPGDALDH1A1HSD17B10
SCHEMBL30403363 0.83 GRM5 (0.46) AR
SCHEMBL29050010 0.81 GRM5 (0.50) CSNK1D
SCHEMBL29514224 0.81 GRM5 (0.50) CSNK1D
SCHEMBL2520258 0.76 THRB (0.43) TSHRKDM4EHSD17B10NPSR1MAPT
SCHEMBL20456849 0.76 PIK3CD (0.35) PRKDC
SCHEMBL30403702 0.75 CYP2C9 (0.46) ALDH1A1KMT2ARAB9AHTTLMNA
SCHEMBL25272227 0.75 KDM4E (0.41) TSHRKDM4EHPGDALDH1A1HSD17B10
SCHEMBL2523357 0.75 KDM4E (0.41) TSHRKDM4EHSD17B10NPSR1MAPT

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 22 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-20230339970-A1 CASEIN KINASE 1 DELTA MODULATORS JANSSEN PHARMACEUTICA NV (BE) 2023-10-26 — — US disclosed
EP-4214214-A1 CASEIN KINASE 1 DELTA MODULATORS JANSSEN Pharmaceutica NV (BE) 2023-07-26 — — EP disclosed
US-20230192699-A1 COMPOUNDS AS CASEIN KINASE INHIBITORS Gritscience Biopharmaceuticals Co., Ltd. (CN) 2023-06-22 — — US disclosed
CN-116171280-A Casein kinase 1 delta modulators 詹森药业有限公司 2023-05-26 — — CN disclosed
EP-4126878-A1 COMPOUNDS AS CASEIN KINASE INHIBITORS Gritscience Biopharmaceuticals Co., Ltd. (CN) 2023-02-08 — — EP disclosed
CN-115335057-A Method for inhibiting casein kinase 北京原基华毅生物科技有限公司 2022-11-11 — — CN disclosed
CN-115298183-A Compounds as casein kinase inhibitors 北京原基华毅生物科技有限公司 2022-11-04 — — CN disclosed
WO-2022058920-A1 CASEIN KINASE 1 DELTA MODULATORS JANSSEN PHARMACEUTICA NV (BE) 2022-03-24 — — WO disclosed
US-9956220-B2 Imidazo-pyridazine derivatives as casein kinase 1 δ/ϵ inhibitors BRISTOL-MYERS SQUIBB COMPANY (US) 2018-05-01 — — US disclosed
US-9956220-B2 Imidazo-pyridazine derivatives as casein kinase 1 δ/ϵ inhibitors BRISTOL-MYERS SQUIBB COMPANY (US) 2018-05-01 — — US disclosed
US-20170137427-A1 IMIDAZO-PYRIDAZINE DERIVATIVES AS CASEIN KINASE 1 DELTA/EPSILON INHIBITORS BRISTOL-MYERS SQUIBB COMPANY (US) 2017-05-18 — — US disclosed
US-20170137427-A1 IMIDAZO-PYRIDAZINE DERIVATIVES AS CASEIN KINASE 1 DELTA/EPSILON INHIBITORS BRISTOL-MYERS SQUIBB COMPANY (US) 2017-05-18 — — US disclosed
EP-3157925-A1 IMIDAZO-PYRIDAZNE DERIVATIVES AS CASEIN KINASE 1 DELTA/EPSILON INHIBITORS Bristol-Myers Squibb Company (US) 2017-04-26 — — EP disclosed
WO-2015195880-A1 IMIDAZO-PYRIDAZNE DERIVATIVES AS CASEIN KINASE 1 DELTA/EPSILON INHIBITORS BRISTOL-MYERS SQUIBB COMPANY (US) 2015-12-23 — — WO disclosed
WO-2015195880-A1 IMIDAZO-PYRIDAZNE DERIVATIVES AS CASEIN KINASE 1 DELTA/EPSILON INHIBITORS BRISTOL-MYERS SQUIBB COMPANY (US) 2015-12-23 — — WO disclosed
EP-2556073-B1 BICYCLIC PYRIDINYL PYRAZOLES BAYER IP GMBH (DE) 2014-07-23 — — EP disclosed
US-8507472-B2 Bicyclic pyridinylpyrazoles BAYER CROPSCIENCE AG (DE) 2013-08-13 — — US disclosed
EP-2556073-A1 BICYCLIC PYRIMIDINYL PYRAZOLES Bayer Intellectual Property GmbH (DE) 2013-02-13 — — EP disclosed
WO-2011124539-A1 BICYCLIC PYRIMIDINYL PYRAZOLES BAYER CROPSCIENCE AG (DE) 2011-10-13 — — WO disclosed
US-20110251178-A1 Bicyclic Pyridinylpyrazoles BAYER CROPSCIENCE AG (DE) 2011-10-13 — — US disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (4 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20110251178-A1 Bicyclic Pyridinylpyrazoles PLPBP, PNPO, PIR TSHR 3280/4885KDM4E 2248/4885HPGD 1305/4885
US-20230339970-A1 CASEIN KINASE 1 DELTA MODULATORS CSNK1D, CSNK1A1, CSNK1G1 TSHR 3280/4885KDM4E 2194/4885HPGD 2461/4885
US-20230192699-A1 COMPOUNDS AS CASEIN KINASE INHIBITORS CSNK2A3, CSNK1A1, CSNK1G3 TSHR 2745/4885KDM4E 836/4885HPGD 3857/4885
US-20170137427-A1 IMIDAZO-PYRIDAZINE DERIVATIVES AS CASEIN KINASE 1 DELTA/EPSILON INHIBITORS CSNK1A1, CSNK1G1, CSNK1E TSHR 3551/4885KDM4E 1468/4885HPGD 2029/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.