Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDE4A | P27815 | 3/20 | 0.38 |
| ▸ | PDE4B | Q07343 | 3/20 | 0.38 |
| ▸ | PDE4C | Q08493 | 3/20 | 0.38 |
| ▸ | PDE4D | Q08499 | 3/20 | 0.38 |
| ▸ | KMO | O15229 | 3/20 | 0.38 |
| ▸ | DHODH | Q02127 | 2/20 | 0.37 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.37 |
| ▸ | ASPH | Q12797 | 1/20 | 0.37 |
| ▸ | KDM8 | Q8N371 | 1/20 | 0.37 |
| ▸ | SCD | O00767 | 3/20 | 0.35 |
| ▸ | MKNK1 | Q9BUB5 | 2/20 | 0.35 |
| ▸ | MKNK2 | Q9HBH9 | 2/20 | 0.35 |
| ▸ | GRIK1 | P39086 | 2/20 | 0.35 |
| ▸ | IP6K1 | Q92551 | 2/20 | 0.35 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL31208526 | 0.81 | DPP4 (0.44) | KDM4EKMT2A | |
| SCHEMBL25234713 | 0.81 | DPP4 (0.44) | KDM4EKMT2A | |
| SCHEMBL25232405 | 0.81 | GABRP (0.39) | PDE4APDE4BPDE4CPDE4DKMO | |
| SCHEMBL29955165 | 0.79 | KMO (0.36) | PDE4APDE4BPDE4CPDE4DKMO | |
| SCHEMBL25235667 | 0.78 | KDM4E (0.47) | KDM4EASPHKDM8 | |
| SCHEMBL31197237 | 0.74 | GRIK1 (0.43) | PDE4APDE4BPDE4CPDE4DSCD | |
| SCHEMBL25213581 | 0.73 | FEN1 (0.36) | PDE4APDE4BPDE4CPDE4DSCD | |
| SCHEMBL31535212 | 0.73 | TSHR (0.41) | PDE4APDE4BPDE4CPDE4DSCD | |
| SCHEMBL23012559 | 0.73 | KMO (0.39) | KMOSCDGRIK1KMT2A | |
| SCHEMBL24468017 | 0.71 | KEAP1 (0.47) | PDE4APDE4BPDE4CPDE4DSCD |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 7 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-12595245-B2 | Inhibitors of MET kinase | CELYN THERAPEUTICS, INC. (US) | 2026-04-07 | — | — | US | disclosed |
| EP-4448510-A1 | INHIBITORS OF MET KINASE | Kinnate Biopharma Inc. (US) | 2024-10-23 | — | — | EP | disclosed |
| CN-118742542-A | Inhibitors of MET kinase | 金耐特生物制药公司 | 2024-10-01 | — | — | CN | disclosed |
| US-20240067626-A1 | INHIBITORS OF MET KINASE | CELYN THERAPEUTICS, INC. | 2024-02-29 | — | — | US | disclosed |
| US-11753395-B2 | Inhibitors of MET kinase | KINNATE BIOPHARMA INC. (US) | 2023-09-12 | — | — | US | disclosed |
| US-20230219929-A1 | INHIBITORS OF MET KINASE | CELYN THERAPEUTICS, INC. | 2023-07-13 | — | — | US | disclosed |
| WO-2023114809-A1 | INHIBITORS OF MET KINASE | KINNATE BIOPHARMA INC. (US) | 2023-06-22 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (4 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-12595245-B2 | Inhibitors of MET kinase | MET, ABL1, ERBB2 | PDE4A 1998/4885PDE4B 2032/4885PDE4C 2321/4885 |
| US-20230219929-A1 | INHIBITORS OF MET KINASE | MET, RET, MERTK | PDE4A 3024/4885PDE4B 2859/4885PDE4C 3067/4885 |
| US-11753395-B2 | Inhibitors of MET kinase | MET, RET, MERTK | PDE4A 3024/4885PDE4B 2859/4885PDE4C 3067/4885 |
| US-20240067626-A1 | INHIBITORS OF MET KINASE | MET, RET, MERTK | PDE4A 3024/4885PDE4B 2859/4885PDE4C 3067/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.