Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 3/20 | 0.59 |
| ▸ | MEN1 | O00255 | 1/20 | 0.59 |
| ▸ | TP53 | P04637 | 1/20 | 0.59 |
| ▸ | CASP3 | P42574 | 1/20 | 0.59 |
| ▸ | HTT | P42858 | 1/20 | 0.59 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.59 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.59 |
| ▸ | SENP7 | Q9BQF6 | 1/20 | 0.59 |
| ▸ | LMNA | P02545 | 1/20 | 0.47 |
| ▸ | TSHR | P16473 | 1/20 | 0.47 |
| ▸ | PGR | P06401 | 5/20 | 0.47 |
| ▸ | PLAU | P00749 | 2/20 | 0.46 |
| ▸ | PLG | P00747 | 1/20 | 0.46 |
| ▸ | PLAT | P00750 | 1/20 | 0.46 |
| ▸ | TDP2 | O95551 | 2/20 | 0.45 |
| ▸ | PELI1 | Q96FA3 | 1/20 | 0.44 |
| ▸ | ALOX5 | P09917 | 1/20 | 0.44 |
| ▸ | SERPINE1 | P05121 | 1/20 | 0.43 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.43 |
| ▸ | SCN5A | Q14524 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1242136 | 0.84 | PGR (0.52) | MAPTMEN1TP53CASP3HTT | |
| Dinitrophenylene SCHEMBL27868275 | 0.83 | MEN1 (0.59) | MAPTMEN1TP53CASP3HTT | |
| SCHEMBL29469269 | 0.82 | KMT2A (0.58) | MAPTMEN1TP53CASP3HTT | |
| SCHEMBL1130974 | 0.82 | KMT2A (0.58) | MAPTMEN1TP53CASP3HTT | |
| SCHEMBL1242359 | 0.82 | MEN1 (0.59) | MAPTMEN1TP53CASP3HTT | |
| SCHEMBL29832245 | 0.81 | PDE4A (0.55) | MAPTHTTKMT2ALMNATSHR | |
| SCHEMBL29628993 | 0.80 | SCN5A (0.54) | MEN1KMT2ASCN5AALDH1A1 | |
| SCHEMBL8477184 | 0.80 | PLAU (0.62) | MAPTMEN1KMT2ANPSR1LMNA | |
| SCHEMBL693976 | 0.78 | HSPB1 (0.55) | MAPTMEN1TP53CASP3HTT | |
| SCHEMBL4516641 | 0.78 | TSHR (0.64) | MAPTLMNATSHRPGRTDP2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-116234797-A | Heterocyclic inhibitors of TEAD for the treatment of cancer | 基因泰克公司 | 2023-06-06 | — | — | CN | disclosed |
| WO-2023097194-A2 | THERAPEUTIC COMPOUNDS AND METHODS OF USE | GENENTECH, INC. (US) | 2023-06-01 | — | — | WO | disclosed |