⚠ Novel chemotype — no close known analogue (best Tanimoto < 0.3). Unexplored chemical space relative to ChEMBL.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL25255412 | 0.68 | — | — | |
| Trifluoroacetic Acid SCHEMBL25296943 | 0.66 | RAB9A (0.33) | — | |
| Hydrochloric Acid SCHEMBL25255172 | 0.66 | USP30 (0.35) | — | |
| SCHEMBL31200178 | 0.66 | MAP3K12 (0.34) | — | |
| SCHEMBL18921367 | 0.62 | PGR (0.30) | — | |
| SCHEMBL18921421 | 0.62 | KCNH2 (0.36) | — | |
| SCHEMBL31200403 | 0.61 | ENPP3 (0.33) | — | |
| SCHEMBL22232716 | 0.61 | TRPV1 (0.34) | — | |
| SCHEMBL22256525 | 0.61 | CHRNB2 (0.36) | — | |
| SCHEMBL25428194 | 0.61 | CHRNB2 (0.36) | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-116547281-A | Isoxazolidines as RIPK1 inhibitors and uses thereof | 赛诺菲 | 2023-08-04 | — | — | CN | disclosed |
| US-20230219937-A1 | ISOXAZOLIDINES AS RIPK1 INHIBITORS AND USE THEREOF | SANOFI (FR) | 2023-07-13 | — | — | US | disclosed |
| US-20230219937-A1 | ISOXAZOLIDINES AS RIPK1 INHIBITORS AND USE THEREOF | SANOFI (FR) | 2023-07-13 | — | — | US | disclosed |
| EP-4157835-A1 | ISOXAZOLIDINES AS RIPK1 INHIBITORS AND USE THEREOF | SANOFI (FR) | 2023-04-05 | — | — | EP | disclosed |