Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTT | P42858 | 2/20 | 0.72 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.72 |
| ▸ | PLK1 | P53350 | 1/20 | 0.59 |
| ▸ | DOT1L | Q8TEK3 | 1/20 | 0.56 |
| ▸ | NPC1 | O15118 | 5/20 | 0.50 |
| ▸ | POLB | P06746 | 3/20 | 0.50 |
| ▸ | MAPT | P10636 | 3/20 | 0.50 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.50 |
| ▸ | HDAC2 | Q92769 | 1/20 | 0.50 |
| ▸ | MEN1 | O00255 | 1/20 | 0.50 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.50 |
| ▸ | ALDH1A1 | P00352 | 6/20 | 0.49 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.49 |
| ▸ | LMNA | P02545 | 1/20 | 0.49 |
| ▸ | RAB9A | P51151 | 5/20 | 0.49 |
| ▸ | BCAT1 | P54687 | 1/20 | 0.48 |
| ▸ | PABPC1 | P11940 | 1/20 | 0.48 |
| ▸ | TAS1R3 | Q7RTX0 | 1/20 | 0.47 |
| ▸ | TAS1R1 | Q7RTX1 | 1/20 | 0.47 |
| ▸ | GAA | P10253 | 2/20 | 0.47 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL25294487 | 0.85 | HTT (0.74) | HTTALOX15PLK1DOT1LNPC1 | |
| SCHEMBL30718649 | 0.84 | ALOX15 (1.00) | HTTALOX15PLK1DOT1LNPC1 | |
| SCHEMBL265015 | 0.84 | ALOX15 (1.00) | HTTALOX15PLK1DOT1LNPC1 | |
| SCHEMBL27928930 | 0.83 | ALOX15 (0.97) | HTTALOX15PLK1DOT1LNPC1 | |
| SCHEMBL20127263 | 0.83 | ALOX15 (0.70) | HTTALOX15PLK1DOT1LNPC1 | |
| SCHEMBL27856105 | 0.81 | DOT1L (0.73) | HTTALOX15PLK1DOT1LNPC1 | |
| SCHEMBL21816441 | 0.81 | ALOX15 (0.68) | HTTALOX15PLK1DOT1LNPC1 | |
| SCHEMBL21816443 | 0.81 | ALOX15 (0.63) | HTTALOX15PLK1DOT1LNPC1 | |
| SCHEMBL5284239 | 0.81 | HTT (0.68) | HTTALOX15PLK1DOT1LNPC1 | |
| SCHEMBL12311610 | 0.80 | ALDH1A1 (0.71) | HTTALOX15PLK1DOT1LNPC1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-12103921-B2 | Chemical compounds | PFIZER INC. (US) | 2024-10-01 | — | — | US | disclosed |
| US-20230382892-A1 | Chemical Compounds | PFIZER INC. (US) | 2023-11-30 | — | — | US | disclosed |
| US-11702405-B2 | Chemical compounds | PFIZER INC. (US) | 2023-07-18 | — | — | US | disclosed |
| US-20220348555-A1 | Chemical Compounds | PFIZER INC. (US) | 2022-11-03 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (4 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-11702405-B2 | Chemical compounds | HBZ, HBB, HBS1L | HTT 96/4885ALOX15 1220/4885PLK1 3065/4885 |
| US-20230382892-A1 | Chemical Compounds | HBZ, HBB, HBS1L | HTT 96/4885ALOX15 1220/4885PLK1 3065/4885 |
| US-12103921-B2 | Chemical compounds | HBZ, HBB, HBS1L | HTT 96/4885ALOX15 1220/4885PLK1 3065/4885 |
| US-20220348555-A1 | Chemical Compounds | HBZ, HBB, HBS1L | HTT 96/4885ALOX15 1220/4885PLK1 3065/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.