Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CRHBP | P24387 | 1/20 | 0.43 |
| ▸ | CRHR2 | Q13324 | 1/20 | 0.43 |
| ▸ | GABRA1 | P14867 | 3/20 | 0.35 |
| ▸ | GABRB2 | P47870 | 3/20 | 0.35 |
| ▸ | HTR1A | P08908 | 3/20 | 0.34 |
| ▸ | DRD2 | P14416 | 3/20 | 0.34 |
| ▸ | DRD4 | P21917 | 3/20 | 0.34 |
| ▸ | HTR2A | P28223 | 3/20 | 0.34 |
| ▸ | HTR2C | P28335 | 3/20 | 0.34 |
| ▸ | DRD3 | P35462 | 3/20 | 0.34 |
| ▸ | ANPEP | P15144 | 2/20 | 0.33 |
| ▸ | DPP4 | P27487 | 2/20 | 0.33 |
| ▸ | MEN1 | O00255 | 1/20 | 0.32 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.32 |
| ▸ | NPEPPS | P55786 | 2/20 | 0.32 |
| ▸ | TSHR | P16473 | 2/20 | 0.31 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.31 |
| ▸ | GAA | P10253 | 1/20 | 0.31 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.31 |
| ▸ | TLR8 | Q9NR97 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Hydrochloric Acid SCHEMBL2523592 | 0.98 | CRHBP (0.42) | CRHBPCRHR2GABRA1GABRB2HTR1A | |
| SCHEMBL14763526 | 0.89 | CRHBP (0.38) | CRHBPCRHR2HTR1ADRD2DRD4 | |
| SCHEMBL2523158 | 0.72 | GABRA1 (0.35) | GABRA1GABRB2HTR2CANPEPDPP4 | |
| SCHEMBL15952821 | 0.69 | BRD9 (0.33) | MEN1KMT2ATSHRALDH1A1NPSR1 | |
| SCHEMBL11504569 | 0.68 | ALDH1A1 (0.40) | CRHBPCRHR2GABRA1GABRB2HTR1A | |
| SCHEMBL11504570 | 0.68 | ALDH1A1 (0.40) | CRHBPCRHR2GABRA1GABRB2HTR1A | |
| Hydrochloric Acid SCHEMBL1697541 | 0.67 | SIGMAR1 (0.38) | MEN1KMT2AALDH1A1GAANPSR1 | |
| SCHEMBL2521179 | 0.66 | ALDH1A1 (0.41) | MEN1KMT2AALDH1A1 | |
| SCHEMBL28045651 | 0.65 | GABRA1 (0.46) | CRHBPCRHR2GABRA1GABRB2HTR1A | |
| Hydrochloric Acid SCHEMBL2525284 | 0.64 | ALDH1A1 (0.40) | MEN1KMT2AALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2104566-B1 | OLEFIN METATHESIS INITIATORS BEARING THIAZOL-2-YLIDENE LIGANDS | CALIFORNIA INST OF TECHN (US) | 2016-01-27 | — | — | EP | disclosed |
| US-8039566-B2 | Olefin metathesis initiators bearing thiazol-2-ylidene ligands | CALIFORNIA INSTITUTE OF TECHNOLOGY (US) | 2011-10-18 | — | — | US | disclosed |
| US-20100144987-A1 | OLEFIN METATHESIS INITIATORS BEARING THIAZOL-2-YLIDENE LIGANDS | CALIFORNIA INSTITUTE OF TECHNOLOGY (US) | 2010-06-10 | — | — | US | disclosed |
| CN-101594937-A | The olefin metathesis initiators that contains inferior thiazol-2-yl part | CALIFORNIA INST OF TECHN (US) | 2009-12-02 | — | — | CN | disclosed |
| EP-2104566-A1 | OLEFIN METATHESIS INITIATORS BEARING THIAZOL-2-YLIDENE LIGANDS | CALIFORNIA INSTITUTE OF TECHNOLOGY (US) | 2009-09-30 | — | — | EP | disclosed |
| WO-2008064223-A1 | OLEFIN METATHESIS INITIATORS BEARING THIAZOL-2-YLIDENE LIGANDS | CALIFORNIA INSTITUTE OF TECHNOLOGY (US) | 2008-05-29 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20100144987-A1 | OLEFIN METATHESIS INITIATORS BEARING THIAZOL-2-YLIDENE LIGANDS | TEC, OXER1, CCNL2 | CRHBP 3776/4885CRHR2 3091/4885GABRA1 4094/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.