Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MKNK1 | Q9BUB5 | 13/20 | 0.48 |
| ▸ | MKNK2 | Q9HBH9 | 12/20 | 0.48 |
| ▸ | PARP1 | P09874 | 1/20 | 0.46 |
| ▸ | DHODH | Q02127 | 1/20 | 0.46 |
| ▸ | PARP2 | Q9UGN5 | 1/20 | 0.46 |
| ▸ | CYP2A6 | P11509 | 1/20 | 0.43 |
| ▸ | SYK | P43405 | 1/20 | 0.41 |
| ▸ | PKN1 | Q16512 | 1/20 | 0.41 |
| ▸ | PKN2 | Q16513 | 1/20 | 0.41 |
| ▸ | CHEK2 | O96017 | 1/20 | 0.41 |
| ▸ | LMNA | P02545 | 1/20 | 0.40 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.40 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.40 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL253870 | 0.81 | CYP11B1 (0.52) | MKNK2PARP1CYP3A4 | |
| SCHEMBL252286 | 0.78 | PARP1 (0.41) | PARP1DHODH | |
| SCHEMBL253898 | 0.77 | SYK (0.41) | MKNK2PARP1SYKLMNA | |
| SCHEMBL253233 | 0.75 | SYK (0.40) | SYK | |
| SCHEMBL255347 | 0.74 | SYK (0.38) | PARP1SYK | |
| SCHEMBL253705 | 0.73 | AURKA (0.47) | PARP1CYP1A2CYP3A4CYP2C19 | |
| SCHEMBL619835 | 0.73 | HTT (0.49) | LMNA | |
| SCHEMBL28566904 | 0.73 | LMNA (0.45) | LMNACYP3A4 | |
| SCHEMBL9375622 | 0.69 | PARP1 (0.46) | MKNK2PARP1DHODHSYKLMNA | |
| SCHEMBL9378964 | 0.69 | PARP1 (0.46) | MKNK2PARP1LMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2401275-A1 | NOVEL BRONCHODILATING DIAZAHETEROARYLS | Respiratorius AB (SE) | 2012-01-04 | — | — | EP | claimed |