Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SYK | P43405 | 5/20 | 0.38 |
| ▸ | CYP11B1 | P15538 | 1/20 | 0.37 |
| ▸ | CYP11B2 | P19099 | 1/20 | 0.37 |
| ▸ | MAPK1 | P28482 | 3/20 | 0.36 |
| ▸ | IRAK4 | Q9NWZ3 | 1/20 | 0.35 |
| ▸ | PARP1 | P09874 | 2/20 | 0.34 |
| ▸ | CNR1 | P21554 | 3/20 | 0.34 |
| ▸ | CNR2 | P34972 | 3/20 | 0.34 |
| ▸ | GRM4 | Q14833 | 1/20 | 0.33 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.33 |
| ▸ | ATM | Q13315 | 1/20 | 0.33 |
| ▸ | ATR | Q13535 | 1/20 | 0.33 |
| ▸ | ROCK2 | O75116 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL253123 | 0.78 | SYK (0.42) | SYKIRAK4KCNH2ROCK2 | |
| SCHEMBL617662 | 0.75 | HTT (0.46) | MAPK1 | |
| SCHEMBL252708 | 0.74 | MKNK1 (0.48) | SYKPARP1 | |
| SCHEMBL253870 | 0.72 | CYP11B1 (0.52) | CYP11B1CYP11B2IRAK4PARP1 | |
| SCHEMBL255348 | 0.71 | NAMPT (0.52) | MAPK1 | |
| SCHEMBL252286 | 0.71 | PARP1 (0.41) | PARP1 | |
| SCHEMBL253705 | 0.70 | AURKA (0.47) | PARP1 | |
| SCHEMBL28566904 | 0.70 | LMNA (0.45) | — | |
| SCHEMBL253898 | 0.69 | SYK (0.41) | SYKIRAK4PARP1 | |
| SCHEMBL5083476 | 0.67 | OPRL1 (0.46) | CYP11B1CYP11B2MAPK1PARP1KCNH2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2401275-A1 | NOVEL BRONCHODILATING DIAZAHETEROARYLS | Respiratorius AB (SE) | 2012-01-04 | — | — | EP | claimed |