SCHEMBL25277366

SCHEMBL25277366

C[Si](C)(C)C#Cc1ccc(CCC(O)S)cc1

nearest known ligand 0.36

Predicted protein targets (top 5)

geneUniProtsupporting neighboursconfidence
ACACB O00763 10/20 0.35
FFAR1 O14842 5/20 0.34
MMP12 P39900 1/20 0.33
MMP13 P45452 1/20 0.33
FFAR4 Q5NUL3 1/20 0.33

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL25270378 0.88 FAAH (0.34) FFAR1FFAR4
SCHEMBL3345157 0.78 ACACB (0.45) ACACBFFAR1FFAR4
SCHEMBL4062990 0.75 ACACB (0.43) ACACBFFAR1FFAR4
SCHEMBL8983717 0.75 GRIN2D (0.37) ACACBFFAR1
SCHEMBL28176135 0.75 ACACB (0.39) ACACBFFAR1
SCHEMBL25276656 0.74 MMP12 (0.36) ACACBFFAR1MMP12MMP13
SCHEMBL28047915 0.74 FFAR1 (0.36) FFAR1FFAR4
SCHEMBL17590559 0.74 ACACB (0.45) ACACB
SCHEMBL6517725 0.73 IDO1 (0.43) FFAR1
SCHEMBL1710488 0.73 NOS3 (0.38) FFAR1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-12534670-B2 Liquid crystal compounds Rolic Technologies AG (CH) 2026-01-27 US disclosed
US-20250066666-A1 LIQUID CRYSTAL COMPOUNDS Rolic Technologies AG (CH) 2025-02-27 US disclosed
EP-4444822-A1 LIQUID CRYSTAL COMPOUNDS Rolic Technologies AG (CH) 2024-10-16 EP disclosed
CN-118318024-A Liquid crystal compound 罗利克技术有限公司 2024-07-09 CN disclosed
WO-2023104545-A1 LIQUID CRYSTAL COMPOUNDS Rolic Technologies AG (CH) 2023-06-15 WO disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-12534670-B2 Liquid crystal compounds SCO2, LBR, C1R ACACB 331/4885FFAR1 714/4885MMP12 4587/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.