SCHEMBL3345157

SCHEMBL3345157

C[Si](C)(C)C#Cc1ccc(CCO)cc1

nearest known ligand 0.45

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
ACACB O00763 1/20 0.45
CA2 P00918 2/20 0.43
TDP1 Q9NUW8 1/20 0.40
FFAR1 O14842 10/20 0.39
CYP4F2 P78329 2/20 0.38
CYP4A11 Q02928 2/20 0.38
FFAR4 Q5NUL3 2/20 0.37
CA12 O43570 1/20 0.36
CA1 P00915 1/20 0.36
CA4 P22748 1/20 0.36
CA6 P23280 1/20 0.36
CA5A P35218 1/20 0.36
CA7 P43166 1/20 0.36
CA9 Q16790 1/20 0.36
CA14 Q9ULX7 1/20 0.36
CA5B Q9Y2D0 1/20 0.36
TSHR P16473 1/20 0.36
KDM4E B2RXH2 1/20 0.35
ALDH1A1 P00352 1/20 0.35
ALOX5 P09917 1/20 0.35

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL1710488 0.84 NOS3 (0.38) CA2FFAR1CA12CA1CA4
SCHEMBL4062990 0.82 ACACB (0.43) ACACBCA2FFAR1FFAR4TSHR
SCHEMBL15062693 0.81 FFAR1 (0.35) FFAR1FFAR4
SCHEMBL28047915 0.81 FFAR1 (0.36) FFAR1FFAR4
SCHEMBL16070697 0.80 ACACB (0.49) ACACBCA2TDP1FFAR1CYP4F2
SCHEMBL10535280 0.79 HRH3 (0.37) TDP1FFAR1TSHRALDH1A1
SCHEMBL7094308 0.79 HSD17B10 (0.46) CA2FFAR1FFAR4CA1TSHR
SCHEMBL22862360 0.79 CA2 (0.54) ACACBCA2TDP1FFAR1CYP4F2
SCHEMBL18642578 0.79 FFAR1 (0.66) FFAR1FFAR4
SCHEMBL1306384 0.78 GABRA1 (0.38) TSHRKDM4EALDH1A1MAPT

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 14 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
WO-2025235719-A1 DIMERIC SMAC MIMETICS USEFUL IN HIV THERAPY VIIV HEALTHCARE COMPANY (US) 2025-11-13 WO disclosed
US-20250136580-A1 INDOLINONE DERIVATIVES AS INHIBITORS OF MATERNAL EMBRYONIC LEUCINE ZIPPER KINASE BOARD OF REGENTS, THE UNIVERSITY OF TEXAS SYSTEM 2025-05-01 US disclosed
US-20240294525-A1 COMPOUNDS AS GLP-1 RECEPTOR AGONISTS AND USES THEREOF CGENETECH (SUZHOU, CHINA) CO., LTD. (CN) 2024-09-05 US disclosed
EP-4406951-A1 COMPOUND AS GLP-1 RECEPTOR AGONIST AND USE THEREOF CGeneTech (Suzhou, China) Co., Ltd. (CN) 2024-07-31 EP disclosed
WO-2023066356-A1 COMPOUND AS GLP-1 RECEPTOR AGONIST AND USE THEREOF 盛世泰科生物医药技术(苏州)有限公司 2023-04-27 WO disclosed
CN-116003393-A Compounds as GLP-1 receptor agonists and uses thereof 盛世泰科生物医药技术(苏州)有限公司 2023-04-25 CN disclosed
US-20210317107-A1 INDOLINONE DERIVATIVES AS INHIBITORS OF MATERNAL EMBRYONIC LEUCINE ZIPPER KINASE BOARD OF REGENTS, THE UNIVERSITY OF TEXAS SYSTEM 2021-10-14 US disclosed
US-20210317107-A1 INDOLINONE DERIVATIVES AS INHIBITORS OF MATERNAL EMBRYONIC LEUCINE ZIPPER KINASE BOARD OF REGENTS, THE UNIVERSITY OF TEXAS SYSTEM 2021-10-14 US disclosed
US-20210149098-A1 OPTICAL ELEMENT, METHOD FOR FORMING PHOTO-ALIGNMENT PATTERN, AND METHOD FOR MANUFACTURING OPTICAL ELEMENT FUJIFILM CORPORATION (JP) 2021-05-20 US disclosed
US-10981896-B2 Indolinone derivatives as inhibitors of maternal embryonic leucine zipper kinase BOARD OF REGENTS, THE UNIVERSITY OF TEXAS SYSTEM (US) 2021-04-20 US disclosed
US-10981896-B2 Indolinone derivatives as inhibitors of maternal embryonic leucine zipper kinase BOARD OF REGENTS, THE UNIVERSITY OF TEXAS SYSTEM (US) 2021-04-20 US disclosed
US-20210002556-A1 COMPOUND, COMPOSITION, CURED OBJECT, OPTICALLY ANISOTROPIC BODY, AND REFLECTIVE FILM FUJIFILM CORPORATION (JP) 2021-01-07 US disclosed
WO-2018160967-A1 INDOLINONE DERIVATIVES AS INHIBITORS OF MATERNAL EMBRYONIC LEUCINE ZIPPER KINASE BOARD OF REGENTS, THE UNIVERSITY OF TEXAS SYSTEM (US) 2018-09-07 WO disclosed
WO-2010043865-A1 INHIBITORS OF HSP90 CHROMA THERAPEUTICS LTD (GB) 2010-04-22 WO disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (5 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20240294525-A1 COMPOUNDS AS GLP-1 RECEPTOR AGONISTS AND USES THEREOF GLP1R, GIPR, GPR119 ACACB 1247/4885CA2 3590/4885TDP1 3616/4885
US-20210317107-A1 INDOLINONE DERIVATIVES AS INHIBITORS OF MATERNAL EMBRYONIC LEUCINE ZIPPER KINASE MELK, HIPK1, HIPK3 ACACB 1578/4885CA2 4524/4885TDP1 2053/4885
US-10981896-B2 Indolinone derivatives as inhibitors of maternal embryonic leucine zipper kinase MELK, HIPK1, HIPK3 ACACB 1440/4885CA2 4553/4885TDP1 2175/4885
US-20210002556-A1 COMPOUND, COMPOSITION, CURED OBJECT, OPTICALLY ANISOTROPIC BODY, AND REFLECTIVE FILM MKI67, RB1, FLNA ACACB 3830/4885CA2 3391/4885TDP1 4194/4885
US-20250136580-A1 INDOLINONE DERIVATIVES AS INHIBITORS OF MATERNAL EMBRYONIC LEUCINE ZIPPER KINASE MELK, HIPK1, HIPK3 ACACB 1578/4885CA2 4524/4885TDP1 2053/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.