SCHEMBL1710488

SCHEMBL1710488

C[Si](C)(C)C#Cc1ccc(CO)cc1

nearest known ligand 0.38

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
NOS3 P29474 1/20 0.38
NOS1 P29475 1/20 0.38
FFAR1 O14842 5/20 0.37
TSHR P16473 1/20 0.36
EGLN1 Q9GZT9 2/20 0.35
HSD17B10 Q99714 1/20 0.33
PRSS1 P07477 1/20 0.33
PRSS2 P07478 1/20 0.33
PRSS3 P35030 1/20 0.33
EGLN3 Q9H6Z9 1/20 0.33
MKNK1 Q9BUB5 1/20 0.32
MKNK2 Q9HBH9 1/20 0.32
VHL P40337 1/20 0.32
ELOC Q15369 1/20 0.32
ELOB Q15370 1/20 0.32
LTA4H P09960 1/20 0.32
CA12 O43570 1/20 0.32
CA1 P00915 1/20 0.32
CA2 P00918 1/20 0.32
CA4 P22748 1/20 0.32

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL16656240 0.89 NOS3 (0.33) NOS3NOS1FFAR1EGLN1GABRA1
SCHEMBL20716885 0.86 NOS3 (0.35) NOS3NOS1FFAR1TSHREGLN1
SCHEMBL22146946 0.85 NOS3 (0.34) NOS3NOS1FFAR1TSHREGLN1
SCHEMBL3345157 0.84 ACACB (0.45) FFAR1TSHRCA12CA1CA2
SCHEMBL15062693 0.84 FFAR1 (0.35) FFAR1GABRA1GABRG2GABRB3GABRA5
SCHEMBL10535280 0.83 HRH3 (0.37) FFAR1TSHRGABRA1GABRG2GABRB3
SCHEMBL1306384 0.82 GABRA1 (0.38) TSHRHSD17B10GABRA1GABRG2GABRB3
SCHEMBL3254459 0.81 CYP2A6 (0.50) FFAR1EGLN1CA2GABRA1GABRG2
SCHEMBL25341764 0.80 FFAR1 (0.43) FFAR1GABRA1GABRG2GABRB3GABRA5
SCHEMBL16070585 0.80 ACACB (0.36)

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 54 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-20110206834-A1 CURABLE COMPOSITION FOR TRANSFER MATERIALS, AND PATTERN FORMING PROCESS SHOWA DENKO K.K. (JP) 2011-08-25 US claimed
EP-2345676-A1 CURABLE COMPOSITION FOR TRANSFER MATERIAL AND PATTERN FORMATION METHOD SHOWA DENKO K.K. (JP) 2011-07-20 EP claimed
US-20250136580-A1 INDOLINONE DERIVATIVES AS INHIBITORS OF MATERNAL EMBRYONIC LEUCINE ZIPPER KINASE BOARD OF REGENTS, THE UNIVERSITY OF TEXAS SYSTEM 2025-05-01 US disclosed
US-20240382465-A1 AROMATIC ACETYLENE DERIVATIVE, AND PREPARATION METHOD THEREFOR AND USE THEREOF ZHEJIANG HISUN PHARMACEUTICAL CO., LTD. (CN) 2024-11-21 US disclosed
EP-4382527-A1 AROMATIC ACETYLENE DERIVATIVE, AND PREPARATION METHOD THEREFOR AND USE THEREOF Zhejiang Hisun Pharmaceutical Co., Ltd. (CN) 2024-06-12 EP disclosed
CN-117769548-A Aromatic acetylene derivative and preparation method and application thereof 浙江海正药业股份有限公司 2024-03-26 CN disclosed
CN-110997658-B Triazole derivatives as hypoxia imaging agents 法国国家科研中心 2024-01-26 CN disclosed
US-11814462-B2 Functionalized cyclic polymers and methods of preparing same UNIVERSITY OF FLORIDA RESEARCH FOUNDATION, INC. (US) 2023-11-14 US disclosed
EP-3894410-B1 SUBSTITUTED XANTHINE DERIVATIVES BOEHRINGER INGELHEIM INT (DE) 2023-10-11 EP disclosed
US-11725000-B2 Apoptosis inhibitors NATIONAL INSTITUTE OF BIOLOGICAL SCIENCES, BEIJING (CN) 2023-08-15 US disclosed
US-20230219964-A1 ANTIBACTERIAL AND ANTIFUNGAL PLEUROMUTILIN CONJUGATES SYDDANSK UNIVERSITET (DK) 2023-07-13 US disclosed
EP-2630250-A1 SENSOR Université de Fribourg (CH) 2013-08-28 EP disclosed
US-20130183704-A1 Labeling Agent and Methods for Simultaneous Sequencing and Quantification of Multiple Peptides and Proteins Using the Same POSTECH ACADEMY-INDUSTRY FOUNDATION (KR) 2013-07-18 US disclosed
EP-2610243-A2 LABELING AGENT AND AMINO ACID SEQUENCE USING SAME, AND METHOD FOR PERFORMING SIMULTANEOUS QUANTITATIVE ANALYSIS OF MULTIPLE PROTEINS Postech Academy-industry Foundation (KR) 2013-07-03 EP disclosed
WO-2012052566-A1 SENSOR UNIVERSITE DE FRIBOURG (CH) 2012-04-26 WO disclosed
US-20110206834-A1 CURABLE COMPOSITION FOR TRANSFER MATERIALS, AND PATTERN FORMING PROCESS SHOWA DENKO K.K. (JP) 2011-08-25 US disclosed
EP-2345676-A1 CURABLE COMPOSITION FOR TRANSFER MATERIAL AND PATTERN FORMATION METHOD SHOWA DENKO K.K. (JP) 2011-07-20 EP disclosed
US-20100300516-A1 MULTILAYER STRUCTURE, PHOTOELECTRIC ELEMENT AND ELECTRONIC APPARATUS SEIKO EPSON CORPORATION (JP) 2010-12-02 US disclosed
US-20100190766-A1 ANTIBACTERIAL AGENTS ACHAOGEN, INC. (US) 2010-07-29 US disclosed
US-6140503-A Organometallic compounds ACADEMIA SINICA (TW) 2000-10-31 US disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (6 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20240382465-A1 AROMATIC ACETYLENE DERIVATIVE, AND PREPARATION METHOD THEREFOR AND USE THEREOF FAR1, ACAD11, ACOX1 NOS3 4403/4885NOS1 2840/4885FFAR1 654/4885
US-11725000-B2 Apoptosis inhibitors BAX, SDHA, SDHB NOS3 2375/4885NOS1 1894/4885FFAR1 4069/4885
US-20230219964-A1 ANTIBACTERIAL AND ANTIFUNGAL PLEUROMUTILIN CONJUGATES HDAC6, Q6ZSR9, MON2 NOS3 4071/4885NOS1 3880/4885FFAR1 2740/4885
US-20100190766-A1 ANTIBACTERIAL AGENTS MRPL21, SI, ABCB11 NOS3 2312/4885NOS1 1438/4885FFAR1 1753/4885
US-20130183704-A1 Labeling Agent and Methods for Simultaneous Sequencing and Quantification of Multiple Peptides and Proteins Using the Same YWHAQ, IAPP, RPS27A NOS3 4443/4885NOS1 4255/4885FFAR1 4759/4885
US-20250136580-A1 INDOLINONE DERIVATIVES AS INHIBITORS OF MATERNAL EMBRYONIC LEUCINE ZIPPER KINASE MELK, HIPK1, HIPK3 NOS3 3000/4885NOS1 3481/4885FFAR1 4382/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.