Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.37 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.37 |
| ▸ | ADORA2A | P29274 | 6/20 | 0.36 |
| ▸ | CNOT7 | Q9UIV1 | 4/20 | 0.35 |
| ▸ | TSHR | P16473 | 3/20 | 0.32 |
| ▸ | NPSR1 | Q6W5P4 | 2/20 | 0.32 |
| ▸ | HTT | P42858 | 1/20 | 0.32 |
| ▸ | USP2 | O75604 | 2/20 | 0.31 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.31 |
| ▸ | HPGD | P15428 | 1/20 | 0.31 |
| ▸ | PDE4A | P27815 | 1/20 | 0.31 |
| ▸ | PDE4B | Q07343 | 1/20 | 0.31 |
| ▸ | PDE4C | Q08493 | 1/20 | 0.31 |
| ▸ | PDE4D | Q08499 | 1/20 | 0.31 |
| ▸ | XBP1 | P17861 | 1/20 | 0.31 |
| ▸ | RBP1 | P09455 | 1/20 | 0.30 |
| ▸ | MEN1 | O00255 | 1/20 | 0.30 |
| ▸ | LMNA | P02545 | 1/20 | 0.30 |
| ▸ | GLA | P06280 | 1/20 | 0.30 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2527366 | 0.85 | ADORA2A (0.38) | ALDH1A1SMN1; SMN2ADORA2APLK1APOBEC3G | |
| SCHEMBL2527116 | 0.82 | ADORA2A (0.38) | ALDH1A1SMN1; SMN2ADORA2ACNOT7PDE4A | |
| SCHEMBL561771 | 0.81 | ADORA2A (0.38) | ALDH1A1SMN1; SMN2ADORA2APLK1APOBEC3G | |
| SCHEMBL2528328 | 0.79 | TSHR (0.38) | ALDH1A1SMN1; SMN2ADORA2ACNOT7TSHR | |
| SCHEMBL2528388 | 0.78 | ALDH1A1 (0.35) | ALDH1A1SMN1; SMN2ADORA2ACNOT7 | |
| SCHEMBL2524833 | 0.78 | PPARG (0.35) | ALDH1A1SMN1; SMN2ADORA2ACNOT7TSHR | |
| SCHEMBL2523023 | 0.77 | MAPT (0.38) | ALDH1A1SMN1; SMN2ADORA2ACNOT7HTT | |
| SCHEMBL2527293 | 0.76 | PPARG (0.38) | ALDH1A1SMN1; SMN2ADORA2ACNOT7TSHR | |
| SCHEMBL2531387 | 0.76 | ALDH1A1 (0.34) | ALDH1A1SMN1; SMN2ADORA2ACNOT7KDM4E | |
| SCHEMBL2524932 | 0.76 | HSP90AA1 (0.38) | ALDH1A1SMN1; SMN2CNOT7HTTLMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8039478-B2 | Purinone derivatives as HM74A agonists | INCYTE CORPORATION (US) | 2011-10-18 | — | — | US | disclosed |