Known targets — ChEMBL curated mechanism
ABL1ADRA1AADRA1BADRA1DADRA2AADRA2BADRA2CADRB2AGTR1BCL2BCL2A1BCL2L1BCL2L10BCL2L2BCRBRAFCHRM1CHRNA10CHRNA9DRD1DRD2DRD3DRD4DRD5EGFRF2FLT1FLT4GCKGHSRGNRHRGRIN1GRIN2AGRIN2BGRIN2CGRIN2DGRIN3AGRIN3BHTR1AHTR1BHTR1DHTR2AHTR2CHTR3AIDH2KDRKITMAOBMCL1MTTPPP4HBPDGFRBPIK3CAPIK3CBPIK3CDPIK3CGPIK3R1PIK3R2PIK3R3PIK3R5PIKFYVEROCK1ROCK2SLC18A2SLC6A2SLC6A3SLC6A4TACR1TUBA1ATUBA1BTUBA1CTUBA3CTUBA3ETUBA4ATUBBTUBB1TUBB2ATUBB2BTUBB3TUBB4ATUBB4BTUBB6TUBB8gyrAgyrBparCparEpol
The experimentally established mechanism targets of Trimethylammonium. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | THRB | P10828 | 1/20 | 0.48 |
| ▸ | TSHR | P16473 | 4/20 | 0.43 |
| ▸ | ALDH1A1 | P00352 | 7/20 | 0.41 |
| ▸ | GAA | P10253 | 2/20 | 0.41 |
| ▸ | MGAM | O43451 | 1/20 | 0.41 |
| ▸ | SI | P14410 | 1/20 | 0.41 |
| ▸ | MGAM2 | Q2M2H8 | 1/20 | 0.41 |
| ▸ | MAPT | P10636 | 2/20 | 0.39 |
| ▸ | GLO1 | Q04760 | 1/20 | 0.38 |
| ▸ | LMNA | P02545 | 1/20 | 0.38 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.38 |
| ▸ | EGLN1 | Q9GZT9 | 1/20 | 0.36 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.36 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.34 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.34 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Sulfuric Acid SCHEMBL631032 | 0.94 | THRB (0.50) | THRBTSHRALDH1A1GAAMGAM | |
| Trimethylammonium SCHEMBL421649 | 0.90 | THRB (0.57) | THRBTSHRALDH1A1GAAMGAM | |
| Trimethylammonium SCHEMBL361090 | 0.89 | THRB (0.46) | THRBTSHRALDH1A1GAAMGAM | |
| Trimethylammonium SCHEMBL31612653 | 0.88 | THRB (0.55) | THRBTSHRALDH1A1GAAMGAM | |
| Trimethylammonium SCHEMBL28463491 | 0.88 | THRB (0.55) | THRBTSHRALDH1A1GAAMGAM | |
| Trimethylammonium SCHEMBL6416933 | 0.88 | THRB (0.55) | THRBTSHRALDH1A1GAAMGAM | |
| Trimethylammonium SCHEMBL332711 | 0.88 | THRB (0.55) | THRBTSHRALDH1A1GAAMGAM | |
| Trimethylammonium SCHEMBL7150631 | 0.88 | THRB (0.55) | THRBTSHRALDH1A1GAAMGAM | |
| Trimethylammonium SCHEMBL31612657 | 0.88 | THRB (0.55) | THRBTSHRALDH1A1GAAMGAM | |
| Trimethylammonium SCHEMBL27578413 | 0.88 | THRB (0.55) | THRBTSHRALDH1A1GAAMGAM |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2023120548-A1 | POLYESTER FILM AND LAMINATED POLYESTER FILM | 三菱ケミカル株式会社 | 2023-06-29 | — | — | WO | disclosed |