Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MGLL | Q99685 | 2/20 | 0.41 |
| ▸ | CCNC | P24863 | 2/20 | 0.38 |
| ▸ | CDK8 | P49336 | 2/20 | 0.38 |
| ▸ | DYRK1A | Q13627 | 1/20 | 0.36 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.33 |
| ▸ | AURKA | O14965 | 1/20 | 0.32 |
| ▸ | TPX2 | Q9ULW0 | 1/20 | 0.32 |
| ▸ | PRKAB2 | O43741 | 5/20 | 0.32 |
| ▸ | PRKAG1 | P54619 | 5/20 | 0.32 |
| ▸ | PRKAA2 | P54646 | 5/20 | 0.32 |
| ▸ | PRKAA1 | Q13131 | 5/20 | 0.32 |
| ▸ | PRKAG3 | Q9UGI9 | 5/20 | 0.32 |
| ▸ | PRKAG2 | Q9UGJ0 | 5/20 | 0.32 |
| ▸ | PRKAB1 | Q9Y478 | 5/20 | 0.32 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.31 |
| ▸ | CSNK2A2 | P19784 | 1/20 | 0.31 |
| ▸ | CSNK2B | P67870 | 1/20 | 0.31 |
| ▸ | CSNK2A1 | P68400 | 1/20 | 0.31 |
| ▸ | F7 | P08709 | 1/20 | 0.31 |
| ▸ | F3 | P13726 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL25233707 | 0.85 | MGLL (0.41) | MGLLCCNCCDK8KDM4E | |
| SCHEMBL29746242 | 0.81 | TSHR (0.41) | CCNCCDK8DYRK1AAURKATPX2 | |
| SCHEMBL25238175 | 0.80 | DYRK1A (0.46) | MGLLDYRK1ACYP3A4PRKAB2PRKAG1 | |
| SCHEMBL25233661 | 0.77 | MGLL (0.48) | MGLLDYRK1ACYP3A4PRKAB2PRKAG1 | |
| SCHEMBL27432704 | 0.71 | KEAP1 (0.38) | CYP3A4KDM4ENOTUMKEAP1 | |
| SCHEMBL31055668 | 0.71 | MGLL (0.48) | MGLLDYRK1AAURKATPX2KDM4E | |
| SCHEMBL29746180 | 0.69 | SLC6A3 (0.43) | CCNCCDK8 | |
| SCHEMBL29746142 | 0.68 | CYP3A4 (0.36) | DYRK1ACYP3A4PRKAB2PRKAG1PRKAA2 | |
| SCHEMBL21250750 | 0.66 | NOTUM (0.40) | DYRK1ACYP3A4NOTUMKEAP1 | |
| SCHEMBL9518431 | 0.66 | CCNC (0.44) | CCNCCDK8DYRK1AKDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20250059185-A1 | BICYCLIC HETEROCYCLIC COMPOUNDS USEFUL AS MONOACYLGLYCEROL LIPASE INHIBITORS | HOFFMANN-LA ROCHE INC. (US) | 2025-02-20 | — | — | US | disclosed |
| EP-4448522-A1 | BICYCLIC HETEROCYCLIC COMPOUNDS USEFUL AS MONOACYLGLYCEROL LIPASE INHIBITORS | F. Hoffmann-La Roche AG (CH) | 2024-10-23 | — | — | EP | disclosed |
| CN-118488953-A | Bicyclic heterocyclic compounds useful as monoacylglycerol lipase inhibitors | 豪夫迈·罗氏有限公司 | 2024-08-13 | — | — | CN | disclosed |
| WO-2023110958-A1 | BICYCLIC HETEROCYCLIC COMPOUNDS USEFUL AS MONOACYLGLYCEROL LIPASE INHIBITORS | F. HOFFMANN-LA ROCHE AG (CH) | 2023-06-22 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20250059185-A1 | BICYCLIC HETEROCYCLIC COMPOUNDS USEFUL AS MONOACYLGLYCEROL LIPASE INHIBITORS | MGLL, LIPC, PNLIP | MGLL 1/4885CCNC 2649/4885CDK8 2883/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.