Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KMT2A | Q03164 | 5/20 | 0.57 |
| ▸ | TET3 | O43151 | 4/20 | 0.57 |
| ▸ | FBXL19 | Q6PCT2 | 4/20 | 0.57 |
| ▸ | TET1 | Q8NFU7 | 4/20 | 0.57 |
| ▸ | KDM2B | Q8NHM5 | 4/20 | 0.57 |
| ▸ | CXXC4 | Q9H2H0 | 4/20 | 0.57 |
| ▸ | KDM2A | Q9Y2K7 | 4/20 | 0.57 |
| ▸ | CXXC5 | Q7LFL8 | 3/20 | 0.57 |
| ▸ | OPRL1 | P41146 | 2/20 | 0.50 |
| ▸ | POLB | P06746 | 1/20 | 0.49 |
| ▸ | OPRM1 | P35372 | 1/20 | 0.47 |
| ▸ | TSHR | P16473 | 2/20 | 0.46 |
| ▸ | CYP2C19 | P33261 | 2/20 | 0.46 |
| ▸ | MEN1 | O00255 | 1/20 | 0.46 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.46 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.46 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.46 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.46 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.46 |
| ▸ | SIGMAR1 | Q99720 | 3/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6017029 | 0.90 | OPRM1 (0.66) | KMT2ATET3FBXL19TET1KDM2B | |
| SCHEMBL27645407 | 0.87 | KMT2A (0.55) | KMT2ATET3FBXL19TET1KDM2B | |
| SCHEMBL11738755 | 0.80 | OPRL1 (0.69) | KMT2AOPRL1POLBOPRM1TSHR | |
| SCHEMBL12216069 | 0.79 | OPRL1 (0.50) | KMT2AOPRL1POLBOPRM1TSHR | |
| Hydrochloric Acid SCHEMBL11744428 | 0.78 | POLB (0.70) | KMT2AOPRL1POLBOPRM1TSHR | |
| SCHEMBL2526312 | 0.76 | OPRM1 (0.59) | KMT2ATET3FBXL19TET1KDM2B | |
| SCHEMBL14520965 | 0.75 | TET3 (0.72) | KMT2ATET3FBXL19TET1KDM2B | |
| SCHEMBL13435360 | 0.75 | KCNA3 (0.59) | KMT2ATET3FBXL19TET1KDM2B | |
| Hydrochloric Acid SCHEMBL2529676 | 0.75 | OPRM1 (0.58) | KMT2ATET3FBXL19TET1KDM2B | |
| SCHEMBL12216179 | 0.74 | KMT2A (0.54) | KMT2ATET3FBXL19TET1KDM2B |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 14 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8039636-B2 | Methods for making 4-tetrazolyl-4-phenylpiperidine compounds | PURDUE PHARMA L.P. (US) | 2011-10-18 | — | — | US | disclosed |
| US-8039636-B2 | Methods for making 4-tetrazolyl-4-phenylpiperidine compounds | PURDUE PHARMA L.P. (US) | 2011-10-18 | — | — | US | disclosed |
| US-8039636-B2 | Methods for making 4-tetrazolyl-4-phenylpiperidine compounds | PURDUE PHARMA L.P. (US) | 2011-10-18 | — | — | US | disclosed |
| US-20090240056-A1 | METHODS FOR MAKING 4-TETRAZOLYL-4-PHENYLPIPERIDINE COMPOUNDS | EURO-CELTIQUE S.A. (LU) | 2009-09-24 | — | — | US | disclosed |
| US-20090240056-A1 | METHODS FOR MAKING 4-TETRAZOLYL-4-PHENYLPIPERIDINE COMPOUNDS | EURO-CELTIQUE S.A. (LU) | 2009-09-24 | — | — | US | disclosed |
| US-20090240056-A1 | METHODS FOR MAKING 4-TETRAZOLYL-4-PHENYLPIPERIDINE COMPOUNDS | EURO-CELTIQUE S.A. (LU) | 2009-09-24 | — | — | US | disclosed |
| US-7557219-B2 | Methods for making 4-tetrazolyl-4-phenylpiperidine compounds | PURDUE PHARMA L.P. (US) | 2009-07-07 | — | — | US | disclosed |
| US-7557219-B2 | Methods for making 4-tetrazolyl-4-phenylpiperidine compounds | PURDUE PHARMA L.P. (US) | 2009-07-07 | — | — | US | disclosed |
| US-7557219-B2 | Methods for making 4-tetrazolyl-4-phenylpiperidine compounds | PURDUE PHARMA L.P. (US) | 2009-07-07 | — | — | US | disclosed |
| US-20070072909-A1 | deblocking, deprotecting; debenzylation; for preventing pain, diarrhea | EURO-CELTIQUE S.A. | 2007-03-29 | — | — | US | disclosed |
| US-20070072909-A1 | deblocking, deprotecting; debenzylation; for preventing pain, diarrhea | EURO-CELTIQUE S.A. | 2007-03-29 | — | — | US | disclosed |
| US-20070072909-A1 | deblocking, deprotecting; debenzylation; for preventing pain, diarrhea | EURO-CELTIQUE S.A. | 2007-03-29 | — | — | US | disclosed |
| EP-1709029-A2 | METHODS FOR MAKING 4-TETRAZOLYL-4-PHENYLPIPERIDINE COMPOUNDS | EURO-CELTIQUE S.A. (LU) | 2006-10-11 | — | — | EP | disclosed |
| WO-2005075455-A2 | METHODS FOR MAKING 4-TETRAZOLYL-4-PHENYLPIPERIDINE COMPOUNDS | EURO-CELTIQUE S.A. (LU) | 2005-08-18 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20070072909-A1 | deblocking, deprotecting; debenzylation; for preventing pain, diarrhea | OPRL1, DECR1, PKD1 | KMT2A 2351/4885TET3 1942/4885FBXL19 2233/4885 |
| US-20090240056-A1 | METHODS FOR MAKING 4-TETRAZOLYL-4-PHENYLPIPERIDINE COMPOUNDS | NAT1, H4C1; H4C2; H4C3; H4C4; H4C5; H4C6; H4C8; H4C9; H4C11; H4C12; H4C13; H4C14; H4C15; H4C16, AHR | KMT2A 1280/4885TET3 869/4885FBXL19 2764/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.