Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NISCH | Q9Y2I1 | 2/20 | 0.46 |
| ▸ | MTOR | P42345 | 1/20 | 0.46 |
| ▸ | ADK | P55263 | 1/20 | 0.46 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.38 |
| ▸ | MEN1 | O00255 | 3/20 | 0.38 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.38 |
| ▸ | TUBB4A | P04350 | 1/20 | 0.37 |
| ▸ | TUBB | P07437 | 1/20 | 0.37 |
| ▸ | TUBA3C | P0DPH7 | 1/20 | 0.37 |
| ▸ | TUBA1B | P68363 | 1/20 | 0.37 |
| ▸ | TUBA4A | P68366 | 1/20 | 0.37 |
| ▸ | TUBB4B | P68371 | 1/20 | 0.37 |
| ▸ | TUBB3 | Q13509 | 1/20 | 0.37 |
| ▸ | TUBB2A | Q13885 | 1/20 | 0.37 |
| ▸ | TUBB8 | Q3ZCM7 | 1/20 | 0.37 |
| ▸ | TUBA3E | Q6PEY2 | 1/20 | 0.37 |
| ▸ | TUBA1A | Q71U36 | 1/20 | 0.37 |
| ▸ | TUBA1C | Q9BQE3 | 1/20 | 0.37 |
| ▸ | TUBB6 | Q9BUF5 | 1/20 | 0.37 |
| ▸ | TUBB2B | Q9BVA1 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4309887 | 0.75 | PARP1 (0.36) | ALDH1A1MEN1KMT2AIDO1KDM4E | |
| SCHEMBL6301542 | 0.73 | NPC1 (0.58) | MTORALDH1A1MEN1KMT2ANPC1 | |
| SCHEMBL4129759 | 0.72 | LRRK2 (0.49) | MTORALDH1A1NPC1RAB9AKDM4E | |
| SCHEMBL5547503 | 0.72 | PDPK1 (0.44) | ALDH1A1MEN1KMT2ATUBB4ATUBB | |
| SCHEMBL26259955 | 0.72 | NISCH (0.61) | NISCHMTORADKALDH1A1MEN1 | |
| SCHEMBL6203822 | 0.71 | KDM4E (0.32) | ALDH1A1IDO1KDM4EHPGDHSD17B10 | |
| SCHEMBL6721218 | 0.70 | IMPDH2 (0.47) | ALDH1A1MEN1KMT2AIDO1RAB9A | |
| SCHEMBL3835052 | 0.70 | CNR1 (0.33) | ALDH1A1TUBB4ATUBBTUBA3CTUBA1B | |
| SCHEMBL1325544 | 0.69 | HSD17B10 (0.54) | NISCHMTORADKALDH1A1MEN1 | |
| SCHEMBL3685297 | 0.69 | ADRA2A (0.45) | NISCHMTORADKALDH1A1MEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 18 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5683999-A | Cyclic urea HIV protease inhibitors | THE DUPONT MERCK PHARMACEUTICAL COMPANY (US) | 1997-11-04 | — | — | US | claimed |
| CN-113135909-B | DPD inhibitor, preparation method thereof, pharmaceutical composition and application | 北京深蓝泰医药科技有限公司 | 2024-03-19 | — | — | CN | disclosed |
| CN-114702443-B | Process for preparing quinolone compounds and intermediates thereof | 重庆文理学院 | 2023-09-19 | — | — | CN | disclosed |
| EP-2112150-B1 | Improved raf inhibitors | FORMA THERAPEUTICS INC (US) | 2013-10-16 | — | — | EP | disclosed |
| US-8232283-B2 | Raf inhibitors | FORMA THERAPEUTICS, INC. (US) | 2012-07-31 | — | — | US | disclosed |
| US-8044173-B2 | Asymmetric synthesis of peptides | UNIVERSITY OF READING (GB) | 2011-10-25 | — | — | US | disclosed |
| US-20110257207-A1 | RAF INHIBITORS | AGENNIX USA INC (US) | 2011-10-20 | — | — | US | disclosed |
| US-7678790-B2 | Platelet ADP receptor inhibitors | PORTOLA PHARMACEUTICALS, INC. (US) | 2010-03-16 | — | — | US | disclosed |
| WO-2009130015-A1 | IMPROVED RAF INHIBITORS | GPC BIOTECH AG (DE) | 2009-10-29 | — | — | WO | disclosed |
| WO-2009130016-A1 | DIHYDROPTERIDINONES AS PLK INHIBITORS | GPC BIOTECH AG (DE) | 2009-10-29 | — | — | WO | disclosed |
| EP-2112150-A1 | Improved raf inhibitors | GPC Biotech AG (DE) | 2009-10-28 | — | — | EP | disclosed |
| EP-2112152-A1 | Dihydropteridinones as Plk Inhibitors | GPC Biotech AG (DE) | 2009-10-28 | — | — | EP | disclosed |
| US-20080281075-A1 | ASYMMETRIC SYNTHESIS OF PEPTIDES | UNIVERSITY OF READING (GB) | 2008-11-13 | — | — | US | disclosed |
| US-20070155719-A1 | Platelet ADP receptor inhibitors | PORTOLA PHARMACEUTICALS, INC. (US) | 2007-07-05 | — | — | US | disclosed |
| EP-1687288-A1 | SUBSTITUTED ARYL CYCLOALKANOL DERIVATIVES AND METHODS OF THEIR USE | Wyeth (US) | 2006-08-09 | — | — | EP | disclosed |
| EP-1673090-A1 | FUSED-ARYL AND HETEROARYL DERIVATIVES AND METHODS OF THEIR USE | Wyeth (US) | 2006-06-28 | — | — | EP | disclosed |
| WO-2005037809-A1 | SUBSTITUTED ARYL CYCLOALKANOL DERIVATIVES AND METHODS OF THEIR USE | WYETH (US) | 2005-04-28 | — | — | WO | disclosed |
| WO-2005037283-A1 | FUSED-ARYL AND HETEROARYL DERIVATIVES AND METHODS OF THEIR USE | WYETH (US) | 2005-04-28 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20110257207-A1 | RAF INHIBITORS | BRAF, RAF1, ARAF | NISCH 1525/4885MTOR 890/4885ADK 514/4885 |
| US-20070155719-A1 | Platelet ADP receptor inhibitors | GP6, P2RY6, PIGS | NISCH 1873/4885MTOR 681/4885ADK 602/4885 |
| US-20080281075-A1 | ASYMMETRIC SYNTHESIS OF PEPTIDES | PTMS, NGLY1, QPCT | NISCH 1734/4885MTOR 3273/4885ADK 3184/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.