Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PARP1 | P09874 | 12/20 | 0.40 |
| ▸ | BRD4 | O60885 | 1/20 | 0.39 |
| ▸ | LMNA | P02545 | 3/20 | 0.38 |
| ▸ | TNKS | O95271 | 2/20 | 0.38 |
| ▸ | PARP2 | Q9UGN5 | 2/20 | 0.38 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.38 |
| ▸ | ADORA1 | P30542 | 1/20 | 0.38 |
| ▸ | CDK6 | Q00534 | 1/20 | 0.38 |
| ▸ | PDE3A | Q14432 | 1/20 | 0.38 |
| ▸ | PARP6 | Q2NL67 | 1/20 | 0.38 |
| ▸ | PARP15 | Q460N3 | 1/20 | 0.38 |
| ▸ | PARP14 | Q460N5 | 1/20 | 0.38 |
| ▸ | PARP10 | Q53GL7 | 1/20 | 0.38 |
| ▸ | TIPARP | Q7Z3E1 | 1/20 | 0.38 |
| ▸ | PARP8 | Q8N3A8 | 1/20 | 0.38 |
| ▸ | PARP16 | Q8N5Y8 | 1/20 | 0.38 |
| ▸ | PARP12 | Q9H0J9 | 1/20 | 0.38 |
| ▸ | TNKS2 | Q9H2K2 | 1/20 | 0.38 |
| ▸ | PARP11 | Q9NR21 | 1/20 | 0.38 |
| ▸ | PARP4 | Q9UKK3 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL25309989 | 0.89 | PARP1 (0.46) | PARP1TNKSPARP2ADORA1CDK6 | |
| SCHEMBL25308646 | 0.85 | PARP1 (0.42) | PARP1BRD4LMNATNKSPARP2 | |
| SCHEMBL25309586 | 0.83 | PARP1 (0.46) | PARP1LMNATNKSPARP2TIPARP | |
| SCHEMBL25310750 | 0.83 | ROCK2 (0.50) | PARP1LMNATNKSPARP2TIPARP | |
| SCHEMBL25307742 | 0.80 | TIPARP (0.51) | PARP1LMNATNKSTIPARPHTT | |
| SCHEMBL25310740 | 0.79 | PARP1 (0.43) | PARP1BRD4TNKSPARP2TDP1 | |
| SCHEMBL30510773 | 0.79 | HTR1A (0.43) | PARP1BRD4LMNATNKSTDP1 | |
| SCHEMBL25307141 | 0.79 | HTR1A (0.43) | PARP1BRD4LMNATNKSTDP1 | |
| Hydrochloric Acid SCHEMBL25308850 | 0.78 | PARP1 (0.48) | PARP1LMNATNKSPARP2ADORA1 | |
| SCHEMBL25309218 | 0.77 | ROCK2 (0.52) | PARP1LMNATNKSTDP1TIPARP |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2023139536-A1 | (4-PIPERAZIN-1YL)-4-ALKYL-PHTHALAZIN-1(2H)-ONE COMPOUNDS AS PARP7 INHIBITORS | RHIZEN PHARMACEUTICALS AG (CH) | 2023-07-27 | — | — | WO | claimed |
| WO-2023139536-A1 | (4-PIPERAZIN-1YL)-4-ALKYL-PHTHALAZIN-1(2H)-ONE COMPOUNDS AS PARP7 INHIBITORS | RHIZEN PHARMACEUTICALS AG (CH) | 2023-07-27 | — | — | WO | disclosed |