Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PARP1 | P09874 | 9/20 | 0.43 |
| ▸ | CDK2 | P24941 | 4/20 | 0.42 |
| ▸ | JUN | P05412 | 3/20 | 0.42 |
| ▸ | MAPK8 | P45983 | 3/20 | 0.42 |
| ▸ | MAPK9 | P45984 | 3/20 | 0.42 |
| ▸ | MAPK10 | P53779 | 2/20 | 0.42 |
| ▸ | BRD4 | O60885 | 1/20 | 0.42 |
| ▸ | TNKS | O95271 | 3/20 | 0.42 |
| ▸ | PARP2 | Q9UGN5 | 2/20 | 0.42 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.41 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.41 |
| ▸ | ADORA1 | P30542 | 1/20 | 0.41 |
| ▸ | CDK6 | Q00534 | 1/20 | 0.41 |
| ▸ | PDE3A | Q14432 | 1/20 | 0.41 |
| ▸ | PARP6 | Q2NL67 | 1/20 | 0.41 |
| ▸ | PARP15 | Q460N3 | 1/20 | 0.41 |
| ▸ | PARP14 | Q460N5 | 1/20 | 0.41 |
| ▸ | PARP10 | Q53GL7 | 1/20 | 0.41 |
| ▸ | TIPARP | Q7Z3E1 | 1/20 | 0.41 |
| ▸ | PARP8 | Q8N3A8 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL25310750 | 0.84 | ROCK2 (0.50) | PARP1TNKSPARP2KMT2ATIPARP | |
| SCHEMBL25309530 | 0.82 | PARP1 (0.48) | PARP1TNKSPARP2KMT2AESR1 | |
| SCHEMBL25307742 | 0.81 | TIPARP (0.51) | PARP1TNKSKMT2ATIPARPESR1 | |
| SCHEMBL25307211 | 0.81 | PARP1 (0.56) | PARP1TNKSPARP2KMT2AADORA1 | |
| SCHEMBL25263299 | 0.81 | TNKS (0.53) | PARP1TNKSPARP2KMT2ATIPARP | |
| SCHEMBL25309503 | 0.79 | PARP1 (0.40) | PARP1BRD4TNKSPARP2TDP1 | |
| Hydrochloric Acid SCHEMBL25309956 | 0.79 | PARP1 (0.48) | PARP1TNKSPARP2KMT2A | |
| SCHEMBL25309218 | 0.78 | ROCK2 (0.52) | PARP1TNKSTDP1KMT2ATIPARP | |
| SCHEMBL30510784 | 0.77 | PARP1 (0.48) | PARP1TNKSPARP2KMT2ATNKS2 | |
| SCHEMBL25310638 | 0.76 | ROCK2 (0.61) | PARP1TNKSPARP2KMT2AESR1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2023139536-A1 | (4-PIPERAZIN-1YL)-4-ALKYL-PHTHALAZIN-1(2H)-ONE COMPOUNDS AS PARP7 INHIBITORS | RHIZEN PHARMACEUTICALS AG (CH) | 2023-07-27 | — | — | WO | claimed |
| WO-2023139536-A1 | (4-PIPERAZIN-1YL)-4-ALKYL-PHTHALAZIN-1(2H)-ONE COMPOUNDS AS PARP7 INHIBITORS | RHIZEN PHARMACEUTICALS AG (CH) | 2023-07-27 | — | — | WO | disclosed |