Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TNKS | O95271 | 2/20 | 0.47 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.47 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.47 |
| ▸ | MAPT | P10636 | 1/20 | 0.47 |
| ▸ | HPGD | P15428 | 1/20 | 0.47 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.47 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.47 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.46 |
| ▸ | PARP1 | P09874 | 16/20 | 0.44 |
| ▸ | PARP2 | Q9UGN5 | 1/20 | 0.42 |
| ▸ | TIPARP | Q7Z3E1 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL30510761 | 1.00 | TNKS (0.47) | TNKSKDM4EALDH1A1MAPTHPGD | |
| SCHEMBL25310056 | 0.86 | TNKS (0.49) | TNKSKMT2APARP1PARP2TIPARP | |
| SCHEMBL30510778 | 0.86 | TNKS (0.49) | TNKSKMT2APARP1PARP2TIPARP | |
| SCHEMBL25308789 | 0.85 | TNKS (0.51) | TNKSKDM4EALDH1A1MAPTHPGD | |
| SCHEMBL25307410 | 0.83 | TNKS (0.55) | TNKSKDM4EALDH1A1MAPTHPGD | |
| SCHEMBL30510770 | 0.81 | TNKS (0.51) | TNKSKDM4EALDH1A1SMN1; SMN2HSD17B10 | |
| SCHEMBL25309030 | 0.81 | TIPARP (0.63) | TNKSKMT2APARP1TIPARP | |
| SCHEMBL25263299 | 0.80 | TNKS (0.53) | TNKSKDM4EMAPTHPGDHSD17B10 | |
| SCHEMBL25308938 | 0.79 | TNKS (0.57) | TNKSKDM4EALDH1A1SMN1; SMN2HSD17B10 | |
| SCHEMBL25310638 | 0.79 | ROCK2 (0.61) | TNKSKDM4EALDH1A1MAPTKMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2023139536-A1 | (4-PIPERAZIN-1YL)-4-ALKYL-PHTHALAZIN-1(2H)-ONE COMPOUNDS AS PARP7 INHIBITORS | RHIZEN PHARMACEUTICALS AG (CH) | 2023-07-27 | — | — | WO | claimed |
| WO-2023139536-A1 | (4-PIPERAZIN-1YL)-4-ALKYL-PHTHALAZIN-1(2H)-ONE COMPOUNDS AS PARP7 INHIBITORS | RHIZEN PHARMACEUTICALS AG (CH) | 2023-07-27 | — | — | WO | disclosed |