Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | POLB | P06746 | 1/20 | 0.53 |
| ▸ | PARP1 | P09874 | 12/20 | 0.50 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.49 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.46 |
| ▸ | TSHR | P16473 | 1/20 | 0.46 |
| ▸ | GAA | P10253 | 1/20 | 0.45 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.45 |
| ▸ | TNKS | O95271 | 2/20 | 0.44 |
| ▸ | LMNA | P02545 | 1/20 | 0.43 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.43 |
| ▸ | PARP2 | Q9UGN5 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Hydrochloric Acid SCHEMBL25310952 | 0.82 | PARP1 (0.55) | PARP1KMT2ATNKSLMNAPARP2 | |
| SCHEMBL25307211 | 0.82 | PARP1 (0.56) | PARP1KMT2ATNKSPARP2 | |
| SCHEMBL25309603 | 0.81 | PARP1 (0.52) | PARP1KMT2ATNKS | |
| SCHEMBL25310638 | 0.81 | ROCK2 (0.61) | PARP1KMT2AALDH1A1TSHRTNKS | |
| SCHEMBL25309242 | 0.80 | PARP1 (0.52) | PARP1KMT2ATSHRTNKS | |
| Hydrochloric Acid SCHEMBL25309956 | 0.80 | PARP1 (0.48) | PARP1KMT2ATNKSLMNAPARP2 | |
| SCHEMBL25311711 | 0.79 | KMT2A (0.48) | PARP1KMT2ATSHRTNKSPARP2 | |
| SCHEMBL25308938 | 0.78 | TNKS (0.57) | PARP1KMT2AALDH1A1TSHRL3MBTL1 | |
| SCHEMBL25309530 | 0.77 | PARP1 (0.48) | PARP1KMT2AALDH1A1TNKSLMNA | |
| SCHEMBL30510766 | 0.76 | TNKS (0.49) | PARP1KMT2ATNKSLMNAMAPK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2023139536-A1 | (4-PIPERAZIN-1YL)-4-ALKYL-PHTHALAZIN-1(2H)-ONE COMPOUNDS AS PARP7 INHIBITORS | RHIZEN PHARMACEUTICALS AG (CH) | 2023-07-27 | — | — | WO | claimed |
| WO-2023139536-A1 | (4-PIPERAZIN-1YL)-4-ALKYL-PHTHALAZIN-1(2H)-ONE COMPOUNDS AS PARP7 INHIBITORS | RHIZEN PHARMACEUTICALS AG (CH) | 2023-07-27 | — | — | WO | disclosed |