Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PARP1 | P09874 | 13/20 | 0.52 |
| ▸ | TNKS | O95271 | 4/20 | 0.52 |
| ▸ | TNKS2 | Q9H2K2 | 3/20 | 0.52 |
| ▸ | DTYMK | P23919 | 2/20 | 0.48 |
| ▸ | CHRM2 | P08172 | 1/20 | 0.48 |
| ▸ | CHRM4 | P08173 | 1/20 | 0.48 |
| ▸ | CHRM1 | P11229 | 1/20 | 0.48 |
| ▸ | CHRM3 | P20309 | 1/20 | 0.48 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.48 |
| ▸ | PDE3B | Q13370 | 1/20 | 0.46 |
| ▸ | PDE3A | Q14432 | 1/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL30510784 | 0.84 | PARP1 (0.48) | PARP1TNKSTNKS2KMT2A | |
| SCHEMBL25310523 | 0.81 | POLB (0.53) | PARP1TNKSKMT2A | |
| Hydrochloric Acid SCHEMBL25310952 | 0.81 | PARP1 (0.55) | PARP1TNKSKMT2A | |
| SCHEMBL25307211 | 0.80 | PARP1 (0.56) | PARP1TNKSTNKS2KMT2APDE3A | |
| SCHEMBL25310638 | 0.79 | ROCK2 (0.61) | PARP1TNKSCHRM1KMT2A | |
| SCHEMBL27884949 | 0.79 | PARP1 (0.61) | PARP1TNKSTNKS2 | |
| Hydrochloric Acid SCHEMBL25309956 | 0.78 | PARP1 (0.48) | PARP1TNKSKMT2A | |
| SCHEMBL7731461 | 0.77 | SIGMAR1 (0.62) | DTYMKCHRM2CHRM4CHRM1CHRM3 | |
| SCHEMBL25308938 | 0.76 | TNKS (0.57) | PARP1TNKSCHRM1KMT2A | |
| SCHEMBL25310750 | 0.76 | ROCK2 (0.50) | PARP1TNKSKMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2023139536-A1 | (4-PIPERAZIN-1YL)-4-ALKYL-PHTHALAZIN-1(2H)-ONE COMPOUNDS AS PARP7 INHIBITORS | RHIZEN PHARMACEUTICALS AG (CH) | 2023-07-27 | — | — | WO | disclosed |