Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PARP1 | P09874 | 12/20 | 0.48 |
| ▸ | TNKS | O95271 | 5/20 | 0.48 |
| ▸ | PARP2 | Q9UGN5 | 5/20 | 0.48 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.46 |
| ▸ | ROCK1 | Q13464 | 2/20 | 0.45 |
| ▸ | ROCK2 | O75116 | 1/20 | 0.45 |
| ▸ | LMNA | P02545 | 1/20 | 0.44 |
| ▸ | ESR1 | P03372 | 1/20 | 0.43 |
| ▸ | C3AR1 | Q16581 | 1/20 | 0.42 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL30510784 | 0.86 | PARP1 (0.48) | PARP1TNKSPARP2KMT2A | |
| Hydrochloric Acid SCHEMBL25309956 | 0.84 | PARP1 (0.48) | PARP1TNKSPARP2KMT2AROCK1 | |
| SCHEMBL25307211 | 0.82 | PARP1 (0.56) | PARP1TNKSPARP2KMT2A | |
| SCHEMBL25310740 | 0.82 | PARP1 (0.43) | PARP1TNKSPARP2KMT2AESR1 | |
| Hydrochloric Acid SCHEMBL25310952 | 0.81 | PARP1 (0.55) | PARP1TNKSPARP2KMT2AROCK1 | |
| Hydrochloric Acid SCHEMBL25308850 | 0.78 | PARP1 (0.48) | PARP1TNKSPARP2KMT2ALMNA | |
| SCHEMBL25310638 | 0.77 | ROCK2 (0.61) | PARP1TNKSPARP2KMT2AROCK1 | |
| SCHEMBL25310523 | 0.77 | POLB (0.53) | PARP1TNKSPARP2KMT2ALMNA | |
| SCHEMBL25309603 | 0.76 | PARP1 (0.52) | PARP1TNKSKMT2A | |
| SCHEMBL25263355 | 0.75 | LMNA (0.68) | PARP1KMT2ALMNAALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2023139536-A1 | (4-PIPERAZIN-1YL)-4-ALKYL-PHTHALAZIN-1(2H)-ONE COMPOUNDS AS PARP7 INHIBITORS | RHIZEN PHARMACEUTICALS AG (CH) | 2023-07-27 | — | — | WO | disclosed |