Known targets — ChEMBL curated mechanism
AGTR1DHFRGABBR1GABBR2GABRA1GABRA2GABRA3GABRA4GABRA5GABRA6GABRB1GABRB2GABRB3GABRDGABREGABRG1GABRG2GABRG3GABRPGABRQGARTNR3C2PBP2XPTGS1PTGS2VKORC1blablaT-3blaT-4blaT-5blaT-6dacAdacBdacCfolAftsImrcAmrcBmrdApbp1apbp1bpbp2apbp2bpbp3polthyA
The experimentally established mechanism targets of Potassium Ion. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TSHR | P16473 | 3/20 | 0.43 |
| ▸ | LMNA | P02545 | 1/20 | 0.43 |
| ▸ | THRB | P10828 | 1/20 | 0.40 |
| ▸ | CA1 | P00915 | 1/20 | 0.36 |
| ▸ | CES1 | P23141 | 6/20 | 0.35 |
| ▸ | CES2 | O00748 | 5/20 | 0.35 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.33 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.33 |
| ▸ | SLC22A1 | O15245 | 2/20 | 0.32 |
| ▸ | SLC22A2 | O15244 | 1/20 | 0.32 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.32 |
| ▸ | LSS | P48449 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Potassium Ion SCHEMBL955226 | 0.96 | — | — | |
| Potassium Ion SCHEMBL31202579 | 0.96 | TSHR (0.46) | TSHRLMNATHRBCA1CES1 | |
| SCHEMBL29973212 | 0.96 | TSHR (0.46) | TSHRLMNATHRBCA1CES1 | |
| SCHEMBL12274283 | 0.96 | TSHR (0.46) | TSHRLMNATHRBCA1CES1 | |
| Potassium Ion SCHEMBL17113317 | 0.96 | TSHR (0.46) | TSHRLMNATHRBCA1CES1 | |
| SCHEMBL74117 | 0.96 | — | — | |
| SCHEMBL27616519 | 0.96 | TSHR (0.46) | TSHRLMNATHRBCA1CES1 | |
| Potassium Ion SCHEMBL37894 | 0.96 | — | — | |
| Potassium Ion SCHEMBL3888413 | 0.96 | TSHR (0.46) | TSHRLMNATHRBCA1CES1 | |
| SCHEMBL31161204 | 0.92 | TSHR (0.43) | TSHRLMNATHRBCA1CES1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2023139125-A1 | IMPROVED PROCESS FOR PREPARATION OF COPANLISIB | SYNTHON B.V. (NL) | 2023-07-27 | — | — | WO | claimed |
| WO-2023139125-A1 | IMPROVED PROCESS FOR PREPARATION OF COPANLISIB | SYNTHON B.V. (NL) | 2023-07-27 | — | — | WO | disclosed |