Known targets — ChEMBL curated mechanism
ABCC9ABL1ACEACHEACVR1ADORA1ADORA2AADORA2BADORA3ADRA1AADRA1BADRA1DADRA2AADRA2BADRA2CADRB1ADRB2ADRB3AGTR1ALOX5ATP4AATP4BBCRBTKCACNA1ACACNA1BCACNA1CCACNA1DCACNA1ECACNA1FCACNA1GCACNA1HCACNA1ICACNA1SCACNA2D1CACNA2D2CACNA2D3CACNA2D4CACNB1CACNB2CACNB3CACNB4CACNG1CACNG2CACNG3CACNG4CACNG5CACNG6CACNG7CACNG8CALCRLCFBCHRM1CHRM2CHRM3CHRM4CHRM5CHRNA1CHRNB1CHRNDCHRNECHRNGCRBNCUL4ACXCR1CXCR2DDB1DDCDHFRDPP4DRD2DRD3DRD4EGFRERBB2ERBB4ESR1ESR2FDPSFKBP1AFLT1FLT3FLT4GARTGHSRGRIA1GRIA2GRIA3GRIA4GRIK1GRIK2GRIK3GRIK4GRIK5GRIN2AGSK3AGSK3BHDAC1HDAC10HDAC11HDAC2HDAC3HDAC4HDAC5HDAC6HDAC7HDAC8HDAC9HRH1HTR1AHTR1BHTR1DHTR1EHTR1FHTR2AHTR2BHTR2CHTR3AHTR3BHTR3CHTR3DHTR3EHTR4HTR5AHTR6HTR7IDH1IDH2IMPA1ITGA2BITGB3JAK1JAK2JAK3KCNJ11KCNK3KCNK9KDRKITMEN1METMMP1MMP13MMP7MMP8NANOD2NS5bODC1OPG057OPRD1OPRK1OPRM1PPARP1PARP2PDE3APDE3BPDE4APDE4BPDE4CPDE4DPDGFRBPIK3CAPIK3CBPIK3CDPIK3CGPIK3R1PIK3R2PIK3R3PIK3R5PKLRPPARDPPATPTGS1PTGS2RBX1ROCK1ROCK2RRM1RRM2RRM2BSCN10ASCN11ASCN1ASCN2ASCN3ASCN4ASCN5ASCN7ASCN8ASCN9ASCNN1ASCNN1BSCNN1GSIGMAR1SLC10A2SLC5A2SLC6A2SLC6A3SLC6A4SLC9A3SYKTACR1THRATHRBTOP1TUBA1ATUBA1BTUBA1CTUBA3CTUBA3ETUBA4ATUBBTUBB1TUBB2ATUBB2BTUBB3TUBB4ATUBB4BTUBB6TUBB8TYK2TYMSVDRampCblablaT-3blaT-4blaT-5blaT-6blaUOE-1dacAdacBdacCfolAfolPftsIgyrAgyrBileSmecAmrcAmrcBmrdAparCparEpbp2pbp4pbpApbpFrplArplBrplCrplDrplErplFrplIrplJrplKrplLrplMrplNrplOrplPrplQrplRrplSrplTrplUrplVrplWrplXrplYrpmArpmBrpmCrpmDrpmErpmE2rpmFrpmGrpmG1rpmG2rpmG3rpmHrpmIrpmJrpsArpsBrpsCrpsDrpsErpsFrpsGrpsHrpsIrpsJrpsKrpsLrpsMrpsNrpsOrpsPrpsQrpsRrpsSrpsTrpsUthyAykgMykgO
The experimentally established mechanism targets of Terpyridine. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | BTK known ✓ | Q06187 | 1/20 | 0.41 |
| ▸ | KDM4E | B2RXH2 | 9/20 | 0.82 |
| ▸ | TP53 | P04637 | 4/20 | 0.82 |
| ▸ | ALOX15 | P16050 | 4/20 | 0.82 |
| ▸ | L3MBTL1 | Q9Y468 | 4/20 | 0.82 |
| ▸ | SMN1; SMN2 | Q16637 | 4/20 | 0.82 |
| ▸ | CCR1 | P32246 | 3/20 | 0.82 |
| ▸ | CCR5 | P51681 | 3/20 | 0.82 |
| ▸ | CCR8 | P51685 | 3/20 | 0.82 |
| ▸ | LMNA | P02545 | 3/20 | 0.82 |
| ▸ | TDP1 | Q9NUW8 | 3/20 | 0.82 |
| ▸ | HTT | P42858 | 2/20 | 0.82 |
| ▸ | ALPL | P05186 | 2/20 | 0.82 |
| ▸ | HSP90AA1 | P07900 | 1/20 | 0.82 |
| ▸ | ALPI | P09923 | 1/20 | 0.82 |
| ▸ | ALPG | P10696 | 1/20 | 0.82 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.82 |
| ▸ | METAP1 | P53582 | 2/20 | 0.64 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.64 |
| ▸ | POLB | P06746 | 1/20 | 0.64 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Terpyridine SCHEMBL2995843 | 0.98 | KDM4E (0.86) | KDM4ETP53ALOX15L3MBTL1SMN1; SMN2 | |
| Terpyridine SCHEMBL30610400 | 0.93 | KDM4E (0.95) | KDM4ETP53ALOX15L3MBTL1SMN1; SMN2 | |
| Terpyridine SCHEMBL30610399 | 0.93 | KDM4E (0.95) | KDM4ETP53ALOX15L3MBTL1SMN1; SMN2 | |
| Terpyridine SCHEMBL5396565 | 0.91 | KDM4E (0.90) | KDM4ETP53ALOX15L3MBTL1SMN1; SMN2 | |
| SCHEMBL30172832 | 0.91 | KDM4E (1.00) | KDM4ETP53ALOX15L3MBTL1SMN1; SMN2 | |
| Terpyridine SCHEMBL29357603 | 0.91 | KDM4E (1.00) | KDM4ETP53ALOX15L3MBTL1SMN1; SMN2 | |
| SCHEMBL7964803 | 0.91 | KDM4E (1.00) | KDM4ETP53ALOX15L3MBTL1SMN1; SMN2 | |
| Terpyridine SCHEMBL57442 | 0.91 | KDM4E (1.00) | KDM4ETP53ALOX15L3MBTL1SMN1; SMN2 | |
| Terpyridine SCHEMBL1451348 | 0.89 | KDM4E (0.78) | KDM4ETP53ALOX15L3MBTL1SMN1; SMN2 | |
| Terpyridine SCHEMBL7546808 | 0.88 | KDM4E (0.86) | KDM4ETP53ALOX15L3MBTL1SMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20150311556-A1 | PLATINUM ADLAYERED RUTHENIUM NANOPARTICLES, METHOD FOR PREPARING, AND USES THEREOF | GEORGETOWN UNIVERSITY (US) | 2015-10-29 | — | — | US | disclosed |
| US-9105934-B2 | Platinum adlayered ruthenium nanoparticles, method for preparing, and uses thereof | GEORGETOWN UNIVERSITY (US) | 2015-08-11 | — | — | US | disclosed |
| US-20110256469-A1 | Platinum Adlayered Ruthenium Nanoparticles, Method for Preparing, and Uses Thereof | GEORGETOWN UNIVERSITY (US) | 2011-10-20 | — | — | US | disclosed |
| WO-2003006434-A1 | METAL COMPLEXES FOR USE IN BORON NEUTRON CAPTURE THERAPY | THE UNIVERSITY OF ADELAIDE (AU) | 2003-01-23 | — | — | WO | disclosed |