Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NOS3 | P29474 | 1/20 | 0.41 |
| ▸ | NOS1 | P29475 | 1/20 | 0.41 |
| ▸ | NOS2 | P35228 | 1/20 | 0.41 |
| ▸ | CHRNB4 | P30926 | 1/20 | 0.36 |
| ▸ | CHRNA3 | P32297 | 1/20 | 0.36 |
| ▸ | CHRNA7 | P36544 | 1/20 | 0.35 |
| ▸ | PGR | P06401 | 5/20 | 0.35 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.33 |
| ▸ | CYP2C19 | P33261 | 2/20 | 0.33 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.33 |
| ▸ | RAD52 | P43351 | 1/20 | 0.33 |
| ▸ | DPP4 | P27487 | 1/20 | 0.33 |
| ▸ | DPP8 | Q6V1X1 | 1/20 | 0.33 |
| ▸ | DPP7 | Q9UHL4 | 1/20 | 0.33 |
| ▸ | KDM1A | O60341 | 1/20 | 0.33 |
| ▸ | NPC1 | O15118 | 1/20 | 0.33 |
| ▸ | RAB9A | P51151 | 1/20 | 0.33 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.33 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.33 |
| ▸ | KEAP1 | Q14145 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL25323166 | 0.91 | NOS1 (0.49) | NOS3NOS1NOS2CHRNB4CHRNA3 | |
| SCHEMBL25323163 | 0.91 | NOS1 (0.49) | NOS3NOS1NOS2CHRNB4CHRNA3 | |
| SCHEMBL25323286 | 0.75 | NOS3 (0.35) | NOS3NOS1NOS2CHRNB4CHRNA3 | |
| Hydrochloric Acid SCHEMBL8871069 | 0.71 | CHRNB4 (0.41) | CHRNB4CHRNA3PGRCYP1A2CYP2C19 | |
| Biphenyl SCHEMBL27461116 | 0.68 | CES1 (0.54) | CYP2C9SMN1; SMN2 | |
| Trifluoroacetic Acid SCHEMBL12611414 | 0.66 | CES1 (0.52) | CYP2C9SMN1; SMN2 | |
| Biphenyl SCHEMBL4861378 | 0.66 | CES1 (0.52) | CYP2C9SMN1; SMN2 | |
| SCHEMBL20835498 | 0.66 | CHRNB4 (0.46) | NOS3NOS1NOS2CHRNB4CHRNA3 | |
| Trifluoroacetic Acid SCHEMBL25319887 | 0.66 | PGR (0.37) | NOS3NOS1NOS2CHRNB4CHRNA3 | |
| SCHEMBL9542642 | 0.65 | RAB9A (0.39) | CHRNB4CHRNA3NPC1RAB9ASMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2023146990-A1 | COMPOUNDS AND METHODS OF USE | TANGO THERAPEUTICS, INC. (US) | 2023-08-03 | — | — | WO | disclosed |