Predicted protein targets (top 6)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LIPE | Q05469 | 7/20 | 0.48 |
| ▸ | CHRNA7 | P36544 | 2/20 | 0.43 |
| ▸ | HCRTR1 | O43613 | 8/20 | 0.42 |
| ▸ | EIF2AK4 | Q9P2K8 | 1/20 | 0.41 |
| ▸ | CNR1 | P21554 | 1/20 | 0.40 |
| ▸ | BCHE | P06276 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL30553324 | 1.00 | LIPE (0.48) | LIPECHRNA7HCRTR1EIF2AK4CNR1 | |
| SCHEMBL30327861 | 0.90 | LIPE (0.49) | LIPECHRNA7BCHE | |
| SCHEMBL23850304 | 0.85 | HSD11B1 (0.47) | LIPE | |
| SCHEMBL21606867 | 0.84 | LIPE (0.62) | LIPEBCHE | |
| SCHEMBL29913011 | 0.84 | LIPE (0.62) | LIPEBCHE | |
| SCHEMBL25252811 | 0.81 | EIF2AK4 (0.39) | EIF2AK4 | |
| SCHEMBL23850247 | 0.81 | GPR119 (0.49) | CHRNA7EIF2AK4 | |
| SCHEMBL29912781 | 0.80 | LIPE (0.48) | LIPECHRNA7HCRTR1BCHE | |
| SCHEMBL22797267 | 0.79 | OXTR (0.42) | — | |
| SCHEMBL29427110 | 0.78 | SCN9A (0.43) | LIPEEIF2AK4BCHE |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20250099448-A1 | HETEROCYCLIC COMPOUNDS | HOFFMANN-LA ROCHE INC. (US) | 2025-03-27 | — | — | US | disclosed |
| WO-2023144160-A1 | NEW HETEROCYCLIC COMPOUNDS | F. HOFFMANN-LA ROCHE AG (CH) | 2023-08-03 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20250099448-A1 | HETEROCYCLIC COMPOUNDS | OPRM1, CYP1A1, CYP3A4 | LIPE 3975/4885CHRNA7 703/4885HCRTR1 41/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.