Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | OPRM1 | P35372 | 7/20 | 0.45 |
| ▸ | OPRK1 | P41145 | 6/20 | 0.45 |
| ▸ | OPRL1 | P41146 | 6/20 | 0.45 |
| ▸ | NOTUM | Q6P988 | 1/20 | 0.43 |
| ▸ | CCKBR | P32239 | 2/20 | 0.41 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.41 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.40 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.40 |
| ▸ | LMNA | P02545 | 1/20 | 0.40 |
| ▸ | HTT | P42858 | 1/20 | 0.40 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.40 |
| ▸ | TSHR | P16473 | 1/20 | 0.40 |
| ▸ | NPC1 | O15118 | 1/20 | 0.40 |
| ▸ | RAB9A | P51151 | 1/20 | 0.40 |
| ▸ | MCOLN3 | Q8TDD5 | 1/20 | 0.40 |
| ▸ | PYGL | P06737 | 2/20 | 0.39 |
| ▸ | PYGM | P11217 | 2/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL27057498 | 0.83 | KMT2A (0.45) | OPRM1OPRK1OPRL1CCKBR | |
| SCHEMBL3785883 | 0.78 | AADAT (0.56) | PYGLPYGM | |
| SCHEMBL4800991 | 0.76 | PYGL (0.43) | LMNAPYGLPYGM | |
| SCHEMBL4800980 | 0.76 | PYGL (0.43) | LMNAPYGLPYGM | |
| SCHEMBL14169878 | 0.74 | OPRM1 (0.52) | OPRM1OPRK1OPRL1NOTUMNPSR1 | |
| SCHEMBL29073300 | 0.73 | OPRM1 (0.44) | OPRM1OPRK1OPRL1NOTUMALDH1A1 | |
| SCHEMBL14169879 | 0.72 | OPRM1 (0.50) | OPRM1OPRK1OPRL1NOTUM | |
| SCHEMBL14170209 | 0.72 | OPRM1 (0.46) | OPRM1OPRK1OPRL1NOTUMNPSR1 | |
| SCHEMBL25329754 | 0.71 | ALDH1A1 (0.37) | ALDH1A1HTTTSHRPYGLPYGM | |
| SCHEMBL14170005 | 0.70 | OPRM1 (0.44) | OPRM1OPRK1OPRL1NOTUMALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20240025856-A1 | 1,2,3,4-TETRAHYDROQUINOLINE DERIVATIVES AS INHIBITORS OF THE YAP/TAZ-TEAD ACTIVATION FOR TREATING CANCER | CISTIM LEUVEN VZW (BE) | 2024-01-25 | — | — | US | disclosed |
| EP-4222143-A1 | 1,2,3,4-TETRAHYDROQUINOLINE DERIVATIVES AS INHIBITORS OF THE YAP/TAZ-TEAD ACTIVATION FOR TREATING CANCER | Katholieke Universiteit Leuven (BE) | 2023-08-09 | — | — | EP | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20240025856-A1 | 1,2,3,4-TETRAHYDROQUINOLINE DERIVATIVES AS INHIBITORS OF THE YAP/TAZ-TEAD ACTIVATION FOR TREATING CANCER | YAP1, TEAD2, TEAD1 | OPRM1 3736/4885OPRK1 2777/4885OPRL1 4395/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.