Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAOA | P21397 | 9/20 | 0.66 |
| ▸ | MAOB | P27338 | 9/20 | 0.66 |
| ▸ | CLK4 | Q9HAZ1 | 4/20 | 0.43 |
| ▸ | USP2 | O75604 | 3/20 | 0.43 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.43 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.43 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.43 |
| ▸ | CYP2D6 | P10635 | 2/20 | 0.43 |
| ▸ | CYP2C19 | P33261 | 2/20 | 0.43 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.43 |
| ▸ | POLB | P06746 | 3/20 | 0.41 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.41 |
| ▸ | DYRK1A | Q13627 | 2/20 | 0.41 |
| ▸ | MAPK9 | P45984 | 1/20 | 0.41 |
| ▸ | MAPK14 | Q16539 | 1/20 | 0.41 |
| ▸ | NPC1 | O15118 | 2/20 | 0.40 |
| ▸ | RAB9A | P51151 | 2/20 | 0.40 |
| ▸ | MAPT | P10636 | 2/20 | 0.40 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.40 |
| ▸ | MEN1 | O00255 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1896823 | 0.80 | MAOA (1.00) | MAOAMAOBCLK4USP2ALDH1A1 | |
| SCHEMBL728003 | 0.79 | MAOA (1.00) | MAOAMAOBALDH1A1CYP3A4CYP2D6 | |
| SCHEMBL1903038 | 0.79 | MAOA (1.00) | MAOAMAOBCLK4USP2ALDH1A1 | |
| SCHEMBL12363257 | 0.78 | MAOA (0.64) | MAOAMAOBCLK4USP2ALDH1A1 | |
| SCHEMBL728246 | 0.78 | MAOA (0.74) | MAOAMAOBALDH1A1CYP1A2CYP3A4 | |
| SCHEMBL2242598 | 0.75 | MAOA (0.51) | MAOAMAOBCLK4USP2ALDH1A1 | |
| SCHEMBL1752207 | 0.74 | MAOA (0.60) | MAOAMAOBCLK4USP2ALDH1A1 | |
| SCHEMBL1899080 | 0.73 | MAOA (1.00) | MAOAMAOBCLK4USP2ALDH1A1 | |
| SCHEMBL3522560 | 0.72 | ALDH1A1 (0.61) | MAOAMAOBCLK4USP2ALDH1A1 | |
| SCHEMBL1747920 | 0.70 | MAOA (0.54) | MAOAMAOBALDH1A1CYP1A2NPC1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 10 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2066653-B1 | 6-1H-IMIDAZO-QUINAZOLINE AND QUINOLINES DERIVATIVES, NEW POTENT ANALGESICS AND ANTI-INFLAMMATORY AGENTS | ROTTAPHARM SPA (IT) | 2012-09-12 | — | — | EP | disclosed |
| EP-2066653-B1 | 6-1H-IMIDAZO-QUINAZOLINE AND QUINOLINES DERIVATIVES, NEW POTENT ANALGESICS AND ANTI-INFLAMMATORY AGENTS | ROTTAPHARM SPA (IT) | 2012-09-12 | — | — | EP | disclosed |
| US-8193353-B2 | 6-1H-imidazo-quinazoline and quinolines derivatives, new potent analgesics and anti-inflammatory agents | ROTTAPHARM S.P.A (IT) | 2012-06-05 | — | — | US | disclosed |
| US-8193353-B2 | 6-1H-imidazo-quinazoline and quinolines derivatives, new potent analgesics and anti-inflammatory agents | ROTTAPHARM S.P.A (IT) | 2012-06-05 | — | — | US | disclosed |
| US-8193353-B2 | 6-1H-imidazo-quinazoline and quinolines derivatives, new potent analgesics and anti-inflammatory agents | ROTTAPHARM S.P.A (IT) | 2012-06-05 | — | — | US | disclosed |
| US-20110257209-A1 | 6-1H-IMIDAZO-QUINAZOLINE AND QUINOLINES DERIVATIVES, NEW POTENT ANALGESICS AND ANTI-INFLAMMATORY AGENTS | ROTTAPHARM S.P.A (IT) | 2011-10-20 | — | — | US | disclosed |
| US-20110257209-A1 | 6-1H-IMIDAZO-QUINAZOLINE AND QUINOLINES DERIVATIVES, NEW POTENT ANALGESICS AND ANTI-INFLAMMATORY AGENTS | ROTTAPHARM S.P.A (IT) | 2011-10-20 | — | — | US | disclosed |
| US-20110257209-A1 | 6-1H-IMIDAZO-QUINAZOLINE AND QUINOLINES DERIVATIVES, NEW POTENT ANALGESICS AND ANTI-INFLAMMATORY AGENTS | ROTTAPHARM S.P.A (IT) | 2011-10-20 | — | — | US | disclosed |
| US-7994181-B2 | 6-1H-imidazo-quinazoline and quinolines derivatives, new potent analgesics and anti-inflammatory agents | ROTTAPHARM S.P.A. (IT) | 2011-08-09 | — | — | US | disclosed |
| US-20090264451-A1 | 6-1H-IMIDAZO-QUINAZOLINE AND QUINOLINES DERIVATIVES, NEW POTENT ANALGESICS AND ANTI-INFLAMMATORY AGENTS | ROTTAPHARM S.P.A. (IT) | 2009-10-22 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20090264451-A1 | 6-1H-IMIDAZO-QUINAZOLINE AND QUINOLINES DERIVATIVES, NEW POTENT ANALGESICS AND ANTI-INFLAMMATORY AGENTS | IL1A, IL6, IL1B | MAOA 3094/4885MAOB 3506/4885CLK4 1694/4885 |
| US-20110257209-A1 | 6-1H-IMIDAZO-QUINAZOLINE AND QUINOLINES DERIVATIVES, NEW POTENT ANALGESICS AND ANTI-INFLAMMATORY AGENTS | IL1A, IL6, IL1B | MAOA 3149/4885MAOB 3479/4885CLK4 1584/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.