SCHEMBL25337017

SCHEMBL25337017

COc1c(C(C)(C)C)cc2c(c1-c1ccccc1C)C=C(C)[CH]2

nearest known ligand 0.33

Predicted protein targets (top 9)

geneUniProtsupporting neighboursconfidence
EGFR P00533 1/20 0.33
ERBB2 P04626 1/20 0.33
TNFRSF1A P19438 1/20 0.32
CYP1A2 P05177 1/20 0.30
CYP2C9 P11712 1/20 0.30
CYP2C19 P33261 1/20 0.30
KDM4E B2RXH2 1/20 0.30
USP2 O75604 1/20 0.30
POLB P06746 1/20 0.30

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL14645800 0.84 PDE4B (0.40) EGFRERBB2TNFRSF1AUSP2POLB
SCHEMBL28013344 0.80 PDE4B (0.36) TNFRSF1A
SCHEMBL25335426 0.80 PTGS2 (0.39)
SCHEMBL14645974 0.78 TDO2 (0.33)
SCHEMBL20165817 0.77 PTGS2 (0.32)
SCHEMBL14645993 0.76 PTGS2 (0.32)
SCHEMBL27076840 0.76 PTGS2 (0.32)
SCHEMBL31179770 0.76 EGFR (0.33) EGFRERBB2TNFRSF1ACYP1A2CYP2C9
SCHEMBL25335194 0.76 EGFR (0.33) EGFRERBB2TNFRSF1ACYP1A2CYP2C9
Lithium SCHEMBL31179826 0.76 TNFRSF1A (0.31) EGFRERBB2TNFRSF1ACYP1A2CYP2C9

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
WO-2023150480-A1 C1 SYMMETRIC 5-OME-6-ALKYL SUBSTITUTED METALLOCENES EXXONMOBIL CHEMICAL PATENTS INC. (US) 2023-08-10 WO disclosed