SCHEMBL14645800

SCHEMBL14645800

COc1c(C(C)(C)C)cc2c(c1-c1ccccc1)C=C(C)[CH]2

nearest known ligand 0.40

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
PDE4B Q07343 6/20 0.40
PDE4A P27815 5/20 0.40
PDE4C Q08493 5/20 0.40
PDE4D Q08499 5/20 0.40
TNFRSF1A P19438 1/20 0.35
ALDH1A1 P00352 2/20 0.32
CYP3A4 P08684 1/20 0.32
PTGS2 P35354 1/20 0.31
TSHR P16473 2/20 0.31
TDP1 Q9NUW8 1/20 0.31
MEN1 O00255 1/20 0.30
MAPT P10636 1/20 0.30
KMT2A Q03164 1/20 0.30
ATM Q13315 1/20 0.30
EGFR P00533 1/20 0.30
ERBB2 P04626 1/20 0.30
SQOR Q9Y6N5 1/20 0.30
USP2 O75604 1/20 0.30
POLB P06746 1/20 0.30
HSD17B10 Q99714 1/20 0.30

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL28013344 0.95 PDE4B (0.36) PDE4BPDE4APDE4CPDE4DTNFRSF1A
SCHEMBL14645974 0.88 TDO2 (0.33) ALDH1A1PTGS2TSHRTDP1
SCHEMBL25335426 0.87 PTGS2 (0.39) ALDH1A1PTGS2TSHRTDP1
SCHEMBL20165817 0.85 PTGS2 (0.32) ALDH1A1PTGS2TSHRTDP1
SCHEMBL25337017 0.84 EGFR (0.33) TNFRSF1AEGFRERBB2USP2POLB
SCHEMBL27076840 0.84 PTGS2 (0.32) ALDH1A1PTGS2TSHRTDP1
SCHEMBL14645993 0.84 PTGS2 (0.32) ALDH1A1PTGS2TSHRTDP1
SCHEMBL23290964 0.84 TDO2 (0.31) PTGS2
SCHEMBL20340256 0.84 TDO2 (0.31)
SCHEMBL28993813 0.83 ALDH1A1 (0.32) ALDH1A1TSHRMEN1KMT2AHSD17B10

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 88 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
CN-106459278-B Improved catalyst system for the preparation of polyethylene copolymers in a high temperature solution polymerization process 博里利斯股份公司 2020-11-06 CN claimed
CN-115298235-B Rigid blown film 博里利斯股份公司 2024-07-05 CN disclosed
CN-116075544-B Polypropylene-based articles with increased surface tension retention 博里利斯股份公司 2024-06-18 CN disclosed
CN-118076654-A Propylene composition for foaming having a high melt flow rate 博里利斯股份公司 2024-05-24 CN disclosed
CN-117980353-A Propylene-butene random copolymer compositions having low extractables content 北欧化工股份公司 2024-05-03 CN disclosed
CN-115667323-B Polypropylene coating composition 北欧化工股份公司 2024-05-03 CN disclosed
CN-117897414-A Process for producing propylene copolymer 博里利斯股份公司 2024-04-16 CN disclosed
CN-115667322-B Polypropylene coating composition 北欧化工股份公司 2024-04-09 CN disclosed
CN-117836365-A Homopolymer-random copolymer blends with beneficial balance of optical and mechanical properties 博里利斯股份公司 2024-04-05 CN disclosed
CN-113195623-B Composition and method for producing the same 博里利斯股份公司 2024-02-06 CN disclosed
EP-2746289-A1 Catalysts Borealis AG (AT) 2014-06-25 EP disclosed
EP-2729479-A1 CATALYSTS Borealis AG (AT) 2014-05-14 EP disclosed
EP-2729529-A1 HETEROPHASIC COPOLYMERS Borealis AG (AT) 2014-05-14 EP disclosed
WO-2014060541-A1 POLYMERISATION PROCESS BOREALIS AG (AT) 2014-04-24 WO disclosed
WO-2014060540-A1 POLYMERISATION PROCESS AND CATALYST BOREALIS AG (AT) 2014-04-24 WO disclosed
EP-2722345-A1 Catalyst Borealis AG (AT) 2014-04-23 EP disclosed
EP-2722344-A1 Polymerisation process Borealis AG (AT) 2014-04-23 EP disclosed
EP-2722346-A1 Polymerisation process and catalyst Borealis AG (AT) 2014-04-23 EP disclosed
WO-2013007650-A1 CATALYSTS BOREALIS AG (AT) 2013-01-17 WO disclosed
WO-2013007664-A1 HETEROPHASIC COPOLYMERS BOREALIS AG (AT) 2013-01-17 WO disclosed