Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LMNA | P02545 | 2/20 | 0.38 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.38 |
| ▸ | POLB | P06746 | 1/20 | 0.38 |
| ▸ | CYP4F2 | P78329 | 2/20 | 0.35 |
| ▸ | CYP4A11 | Q02928 | 2/20 | 0.35 |
| ▸ | DRD1 | P21728 | 3/20 | 0.33 |
| ▸ | GAA | P10253 | 1/20 | 0.32 |
| ▸ | KDM5B | Q9UGL1 | 1/20 | 0.32 |
| ▸ | RXRA | P19793 | 1/20 | 0.31 |
| ▸ | RXRB | P28702 | 1/20 | 0.31 |
| ▸ | RXRG | P48443 | 1/20 | 0.31 |
| ▸ | MEN1 | O00255 | 1/20 | 0.31 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.31 |
| ▸ | PDE1A | P54750 | 1/20 | 0.30 |
| ▸ | PDE1B | Q01064 | 1/20 | 0.30 |
| ▸ | PDE1C | Q14123 | 1/20 | 0.30 |
| ▸ | ESR1 | P03372 | 1/20 | 0.30 |
| ▸ | MAPT | P10636 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL25342251 | 0.89 | ALDH1A1 (0.38) | LMNAALDH1A1POLBCYP4F2CYP4A11 | |
| SCHEMBL15666220 | 0.73 | ALDH1A1 (0.46) | LMNAALDH1A1POLBCYP4F2CYP4A11 | |
| SCHEMBL25968369 | 0.73 | CYP4F2 (0.41) | LMNAALDH1A1POLBCYP4F2CYP4A11 | |
| SCHEMBL13267231 | 0.71 | ALDH1A1 (0.46) | LMNAALDH1A1POLBCYP4F2CYP4A11 | |
| SCHEMBL30268685 | 0.68 | RAB9A (0.44) | LMNAALDH1A1POLBCYP4F2CYP4A11 | |
| SCHEMBL25341195 | 0.68 | RXRA (0.42) | LMNAALDH1A1POLBCYP4F2CYP4A11 | |
| SCHEMBL1008524 | 0.68 | ALDH1A1 (0.48) | LMNAALDH1A1POLBCYP4F2CYP4A11 | |
| SCHEMBL25342107 | 0.67 | ALDH1A1 (0.40) | LMNAALDH1A1POLBCYP4F2CYP4A11 | |
| SCHEMBL31103919 | 0.67 | ALDH1A1 (0.40) | LMNAALDH1A1POLBCYP4F2CYP4A11 | |
| SCHEMBL31104171 | 0.67 | ALDH1A1 (0.40) | LMNAALDH1A1POLBCYP4F2CYP4A11 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20250154139-A1 | PYRIDAZINONE COMPOUNDS AS TRPA1 INHIBITORS | D. E. SHAW RESEARCH, LLC | 2025-05-15 | — | — | US | disclosed |
| EP-4472624-A2 | PYRIDAZINONE COMPOUNDS AS TRPA1 INHIBITORS | D.E. Shaw Research, LLC (US) | 2024-12-11 | — | — | EP | disclosed |
| CN-118973564-A | Pyridazinone compounds as TRPA1 inhibitors | D·E·萧尔研究有限责任公司 | 2024-11-15 | — | — | CN | disclosed |
| WO-2023150591-A2 | PYRIDAZINONE COMPOUNDS AS TRPA1 INHIBITORS | D.E. SHAW RESEARCH, LLC (US) | 2023-08-10 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20250154139-A1 | PYRIDAZINONE COMPOUNDS AS TRPA1 INHIBITORS | TRPA1, TRPV1, TRPV5 | LMNA 1991/4885ALDH1A1 538/4885POLB 4010/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.