⚠ Novel chemotype — no close known analogue (best Tanimoto < 0.3). Unexplored chemical space relative to ChEMBL.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2915154 | 0.72 | DYRK1A (0.32) | — | |
| SCHEMBL1247719 | 0.71 | GAA (0.43) | — | |
| SCHEMBL29067340 | 0.71 | ALDH1A1 (0.34) | — | |
| SCHEMBL25344520 | 0.71 | — | — | |
| SCHEMBL17841780 | 0.69 | GAA (0.39) | — | |
| SCHEMBL34259 | 0.66 | GAA (0.48) | — | |
| SCHEMBL9160695 | 0.65 | NAMPT (0.39) | — | |
| SCHEMBL8654087 | 0.65 | GAA (0.46) | — | |
| Iodide SCHEMBL12466756 | 0.65 | GAA (0.46) | — | |
| Hydrochloric Acid SCHEMBL160640 | 0.65 | GAA (0.46) | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 8 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20250145575-A1 | MACROMOLECULE-SUPPORTED 8-SULFONYL-BENZAZEPINE COMPOUNDS AND THEIR USES | BOLT BIOTHERAPEUTICS, INC. (US) | 2025-05-08 | — | — | US | disclosed |
| US-20250127914-A1 | ANTIBODY-CONJUGATED 8-SULFONYL-BENZAZEPINE COMPOUNDS AND THEIR USES | BOLT BIOTHERAPEUTICS, INC. (US) | 2025-04-24 | — | — | US | disclosed |
| CN-118843480-A | Polymer-supported 8-sulfonyl-benzazepine compounds and uses thereof | 博尔特生物治疗药物有限公司 | 2024-10-25 | — | — | CN | disclosed |
| CN-118843480-A | Polymer-supported 8-sulfonyl-benzazepine compounds and uses thereof | 博尔特生物治疗药物有限公司 | 2024-10-25 | — | — | CN | disclosed |
| CN-118843481-A | Antibody conjugated 8-sulfonyl-benzazepine compounds and uses thereof | 博尔特生物治疗药物有限公司 | 2024-10-25 | — | — | CN | disclosed |
| CN-118843481-A | Antibody conjugated 8-sulfonyl-benzazepine compounds and uses thereof | 博尔特生物治疗药物有限公司 | 2024-10-25 | — | — | CN | disclosed |
| WO-2023154307-A1 | ANTIBODY-CONJUGATED 8-SULFONYL-BENZAZEPINE COMPOUNDS AND THEIR USES | BOLT BIOTHERAPEUTICS, INC. (US) | 2023-08-17 | — | — | WO | disclosed |
| WO-2023154302-A1 | MACROMOLECULE-SUPPORTED 8-SULFONYL-BENZAZEPINE COMPOUNDS AND THEIR USES | BOLT BIOTHERAPEUTICS, INC. (US) | 2023-08-17 | — | — | WO | disclosed |