Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TRPA1 | O75762 | 1/20 | 0.33 |
| ▸ | PIM1 | P11309 | 1/20 | 0.32 |
| ▸ | CSNK1A1 | P48729 | 1/20 | 0.32 |
| ▸ | CDK5 | Q00535 | 1/20 | 0.32 |
| ▸ | ROCK1 | Q13464 | 1/20 | 0.32 |
| ▸ | DYRK1A | Q13627 | 1/20 | 0.32 |
| ▸ | LRRK2 | Q5S007 | 1/20 | 0.32 |
| ▸ | CLK4 | Q9HAZ1 | 1/20 | 0.32 |
| ▸ | DYRK1B | Q9Y463 | 1/20 | 0.32 |
| ▸ | PARP10 | Q53GL7 | 1/20 | 0.30 |
| ▸ | PARP11 | Q9NR21 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL20241845 | 0.72 | CYP2A13 (0.36) | TRPA1PIM1CSNK1A1CDK5ROCK1 | |
| SCHEMBL29790918 | 0.72 | CYP2A13 (0.36) | TRPA1PIM1CSNK1A1CDK5ROCK1 | |
| SCHEMBL10335976 | 0.70 | PIM1 (0.39) | TRPA1PIM1CSNK1A1CDK5ROCK1 | |
| SCHEMBL132547 | 0.69 | MAOA (0.34) | — | |
| SCHEMBL31394006 | 0.68 | ABHD6 (0.33) | TRPA1PIM1CSNK1A1CDK5ROCK1 | |
| SCHEMBL5363757 | 0.68 | ABHD6 (0.33) | TRPA1PIM1CSNK1A1CDK5ROCK1 | |
| SCHEMBL15321041 | 0.64 | MAOA (0.33) | TRPA1 | |
| SCHEMBL3976079 | 0.64 | — | — | |
| SCHEMBL5369024 | 0.64 | PNMT (0.34) | TRPA1PIM1CSNK1A1CDK5ROCK1 | |
| SCHEMBL16111186 | 0.64 | TRPA1 (0.37) | TRPA1PIM1CSNK1A1CDK5ROCK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-4225441-A1 | NEW COMPOUNDS AND THEIR USE AS THERAPEUTICALLY ACTIVE SUBSTANCES IN THE TREATMENT AND/OR PREVENTION OF DISEASES INVOLVING THE RETINAL PIGMENT EPITHELIUM | Endogena Therapeutics, Inc. (US) | 2023-08-16 | — | — | EP | disclosed |