Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.46 |
| ▸ | RAB9A | P51151 | 1/20 | 0.46 |
| ▸ | ALOX5 | P09917 | 1/20 | 0.44 |
| ▸ | MEN1 | O00255 | 2/20 | 0.43 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.43 |
| ▸ | POLB | P06746 | 1/20 | 0.43 |
| ▸ | LPAR1 | Q92633 | 1/20 | 0.42 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.41 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.41 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.41 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.41 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.41 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.41 |
| ▸ | TSHR | P16473 | 2/20 | 0.41 |
| ▸ | ABCB1 | P08183 | 1/20 | 0.41 |
| ▸ | PLA2G4A | P47712 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9093669 | 0.79 | MEN1 (0.45) | ALOX5MEN1KMT2AALDH1A1TSHR | |
| SCHEMBL1025097 | 0.79 | RAB9A (0.52) | SMN1; SMN2RAB9APOLBALDH1A1CYP2C19 | |
| SCHEMBL8455536 | 0.76 | ALDH1A1 (0.49) | MEN1KMT2AALDH1A1TSHR | |
| SCHEMBL2531890 | 0.73 | CYP11B1 (0.52) | SMN1; SMN2RAB9AALOX5MEN1KMT2A | |
| SCHEMBL17410492 | 0.73 | ALDH1A1 (0.47) | SMN1; SMN2RAB9AALDH1A1CYP1A2CYP2C9 | |
| SCHEMBL3711683 | 0.72 | RAB9A (0.54) | SMN1; SMN2RAB9AKMT2AALDH1A1CYP2C19 | |
| SCHEMBL23361721 | 0.72 | RAB9A (0.51) | SMN1; SMN2RAB9AALDH1A1L3MBTL1TSHR | |
| SCHEMBL260297 | 0.71 | ALOX5 (0.76) | SMN1; SMN2RAB9AALOX5KMT2APOLB | |
| SCHEMBL6369409 | 0.71 | CYP4F2 (0.43) | SMN1; SMN2RAB9AALDH1A1L3MBTL1 | |
| Hexane SCHEMBL9090041 | 0.71 | KMT2A (0.46) | SMN1; SMN2RAB9AMEN1KMT2APOLB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2382223-A1 | PHENYLALKYL-IMIDAZOLE-BISPHOSPHONATE COMPOUNDS | Novartis AG (CH) | 2011-11-02 | — | — | EP | disclosed |
| US-20110257131-A1 | PHENYLALKYL-IMIDAZOLE-BISPHOSPHONATE COMPOUNDS | NOVARTIS AG (CH) | 2011-10-20 | — | — | US | disclosed |
| US-20110257131-A1 | PHENYLALKYL-IMIDAZOLE-BISPHOSPHONATE COMPOUNDS | NOVARTIS AG (CH) | 2011-10-20 | — | — | US | disclosed |
| US-20110257131-A1 | PHENYLALKYL-IMIDAZOLE-BISPHOSPHONATE COMPOUNDS | NOVARTIS AG (CH) | 2011-10-20 | — | — | US | disclosed |
| WO-2010076258-A1 | PHENYLALKYL-IMIDAZOLE-BISPHOSPHONATE COMPOUNDS | NOVARTIS AG (CH) | 2010-07-08 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20110257131-A1 | PHENYLALKYL-IMIDAZOLE-BISPHOSPHONATE COMPOUNDS | PTEN, INPP5D, PPIP5K2 | SMN1; SMN2 2330/4885RAB9A 329/4885ALOX5 1605/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.