Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PKM | P14618 | 5/20 | 0.50 |
| ▸ | PIP4K2A | P48426 | 1/20 | 0.50 |
| ▸ | TSHR | P16473 | 1/20 | 0.45 |
| ▸ | NAMPT | P43490 | 3/20 | 0.44 |
| ▸ | ALOX5AP | P20292 | 1/20 | 0.44 |
| ▸ | FEN1 | P39748 | 1/20 | 0.44 |
| ▸ | MMP2 | P08253 | 1/20 | 0.44 |
| ▸ | MEN1 | O00255 | 1/20 | 0.43 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.43 |
| ▸ | POLB | P06746 | 1/20 | 0.43 |
| ▸ | GCK | P35557 | 1/20 | 0.42 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.42 |
| ▸ | USP2 | O75604 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL14132264 | 0.84 | POLB (0.62) | PKMPIP4K2ATSHRMEN1KMT2A | |
| SCHEMBL12169332 | 0.84 | PKM (0.57) | PKMTSHRMEN1KMT2APOLB | |
| SCHEMBL17394167 | 0.84 | PIP4K2A (0.47) | PIP4K2ATSHRNAMPTMMP2KDM4E | |
| SCHEMBL25354281 | 0.83 | PIP4K2A (0.53) | PIP4K2ATSHRNAMPTPOLBKDM4E | |
| SCHEMBL25359305 | 0.80 | ALDH1A1 (0.51) | PIP4K2AKMT2A | |
| SCHEMBL21514947 | 0.77 | POLB (0.50) | PIP4K2ATSHRNAMPTMEN1KMT2A | |
| SCHEMBL16912995 | 0.77 | PKM (0.53) | PKMTSHRMMP2MEN1KMT2A | |
| SCHEMBL11306227 | 0.77 | PKM (0.69) | PKMTSHRMMP2MEN1KMT2A | |
| SCHEMBL24058307 | 0.75 | POLB (0.61) | PKMPIP4K2ANAMPTALOX5APFEN1 | |
| SCHEMBL28290962 | 0.75 | HTR2A (0.43) | PKMPIP4K2ATSHRNAMPTALOX5AP |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2023122778-A1 | PYRIDAZINONE DERIVATIVES USEFUL AS T CELL ACTIVATORS | GOSSAMER BIO SERVICES, INC. (US) | 2023-06-29 | — | — | WO | disclosed |
| WO-2023122778-A1 | PYRIDAZINONE DERIVATIVES USEFUL AS T CELL ACTIVATORS | GOSSAMER BIO SERVICES, INC. (US) | 2023-06-29 | — | — | WO | disclosed |