Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 5/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.41 |
| ▸ | KDM4E | B2RXH2 | 4/20 | 0.41 |
| ▸ | L3MBTL1 | Q9Y468 | 3/20 | 0.41 |
| ▸ | LMNA | P02545 | 2/20 | 0.41 |
| ▸ | ITGB2 | P05107 | 2/20 | 0.39 |
| ▸ | ICAM1 | P05362 | 2/20 | 0.39 |
| ▸ | ITGAL | P20701 | 2/20 | 0.39 |
| ▸ | NPC1 | O15118 | 1/20 | 0.39 |
| ▸ | RAB9A | P51151 | 1/20 | 0.39 |
| ▸ | MPO | P05164 | 2/20 | 0.38 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.38 |
| ▸ | BLM | P54132 | 2/20 | 0.38 |
| ▸ | KDM5A | P29375 | 1/20 | 0.38 |
| ▸ | GFER | P55789 | 1/20 | 0.38 |
| ▸ | PMP22 | Q01453 | 1/20 | 0.38 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.38 |
| ▸ | CES2 | O00748 | 1/20 | 0.37 |
| ▸ | CES1 | P23141 | 1/20 | 0.37 |
| ▸ | NSD2 | O96028 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL30048528 | 0.82 | CES2 (0.50) | ALDH1A1KDM4ECES2CES1TDP1 | |
| SCHEMBL3309453 | 0.82 | CES2 (0.50) | ALDH1A1KDM4ECES2CES1TDP1 | |
| SCHEMBL2645530 | 0.81 | ALDH1A1 (0.42) | MAPTALDH1A1KDM4EL3MBTL1LMNA | |
| SCHEMBL1127907 | 0.78 | CES2 (0.56) | MAPTALDH1A1L3MBTL1LMNAITGB2 | |
| SCHEMBL25363190 | 0.77 | CES2 (0.50) | MAPTALDH1A1L3MBTL1ITGB2ICAM1 | |
| SCHEMBL29442184 | 0.76 | CES2 (0.41) | MAPTL3MBTL1ITGB2ICAM1ITGAL | |
| SCHEMBL23631778 | 0.76 | CES2 (0.41) | MAPTL3MBTL1ITGB2ICAM1ITGAL | |
| SCHEMBL28723694 | 0.74 | KDM4E (0.42) | MAPTALDH1A1KDM4EL3MBTL1LMNA | |
| SCHEMBL21750024 | 0.74 | KEAP1 (0.45) | MAPTALDH1A1KDM4ELMNABLM | |
| SCHEMBL29970839 | 0.73 | CES2 (0.56) | MAPTALDH1A1L3MBTL1LMNAITGB2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20250154130-A1 | NOVEL THR BETA ANALOGS AND USES THEREOF | LSI FINANCING LLC, AS ADMINISTRATIVE AGENT | 2025-05-15 | — | — | US | disclosed |
| EP-4476209-A1 | THR BETA ANALOGS AND USES THEREOF | Madrigal Pharmaceuticals, Inc. (US) | 2024-12-18 | — | — | EP | disclosed |
| WO-2023154842-A1 | THR BETA ANALOGS AND USES THEREOF | MADRIGAL PHARMACEUTICALS, INC. (US) | 2023-08-17 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20250154130-A1 | NOVEL THR BETA ANALOGS AND USES THEREOF | THRB, THRA, TSHR | MAPT 2343/4885ALDH1A1 2389/4885KDM4E 4475/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.