SCHEMBL25370429

SCHEMBL25370429

Cc1nc(Br)ccc1S(=O)(=O)N1CC2(CN(C(=O)O)C2)C1

nearest known ligand 0.33

Predicted protein targets (top 15)

geneUniProtsupporting neighboursconfidence
▸ LMNA P02545 3/20 0.33
▸ HSD17B10 Q99714 2/20 0.33
▸ ALDH1A1 P00352 4/20 0.32
▸ SMN1; SMN2 Q16637 3/20 0.32
▸ TSHR P16473 2/20 0.32
▸ KDM4E B2RXH2 2/20 0.32
▸ GAA P10253 1/20 0.32
▸ HPGD P15428 1/20 0.32
▸ HTT P42858 1/20 0.32
▸ NPSR1 Q6W5P4 1/20 0.32
▸ EPHX2 P34913 1/20 0.31
▸ USP9X Q93008 1/20 0.31
▸ CYP3A4 P08684 1/20 0.31
▸ ALOX15 P16050 1/20 0.30
▸ SPR P35270 1/20 0.30

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL25371565 0.86 F13A1 (0.39) EPHX2
SCHEMBL25371394 0.82 TRPV4 (0.44) KDM4EGAAUSP9X
SCHEMBL25370722 0.81 CHEK1 (0.34) ALDH1A1
SCHEMBL25370107 0.75 SMN1; SMN2 (0.35) ALDH1A1SMN1; SMN2KDM4EHPGDNPSR1
SCHEMBL31467619 0.74 TGM2 (0.41) EPHX2
SCHEMBL26065927 0.73 TGM2 (0.52) LMNAHSD17B10ALDH1A1SMN1; SMN2TSHR
SCHEMBL26065944 0.70 ALDH1A1 (0.51) LMNAALDH1A1SMN1; SMN2TSHRKDM4E
SCHEMBL14920210 0.70 EPHX2 (0.52) ALDH1A1TSHRHTTEPHX2ALOX15
SCHEMBL25370521 0.70 TGM2 (0.39) EPHX2
SCHEMBL25368335 0.70 TRPV4 (0.42) EPHX2

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-20250171463-A1 EMOPAMIL-BINDING PROTEIN INHIBITORS AND USES THEREOF BIOGEN MA INC. 2025-05-29 — — US disclosed
EP-4482587-A1 EMOPAMIL-BINDING PROTEIN INHIBITORS AND USES THEREOF Biogen MA Inc. (US) 2025-01-01 — — EP disclosed
WO-2023164063-A1 EMOPAMIL-BINDING PROTEIN INHIBITORS AND USES THEREOF BIOGEN MA INC. (US) 2023-08-31 — — WO disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20250171463-A1 EMOPAMIL-BINDING PROTEIN INHIBITORS AND USES THEREOF EBPL, EBP, CREBBP LMNA 2525/4885HSD17B10 2354/4885ALDH1A1 3076/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.

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